Editor's Summary
16 November 2006
Let them eat cake
You can have your cake and eat it. Fat, healthy and tipsy. Fountain of youth. These headlines and more greeted online publication of the Article 'Resveratrol improves health and survival of mice on a high-calorie diet'. What the paper does show is that consumption of resveratrol at doses achievable in humans (but not from red wine — the hundreds of bottles a day needed would have side effects) can reproduce many of the physiological effects of a low-calorie diet in mice, improving health and survival. Read the small print in this issue.
News and Views: Medicine: Grapes versus gluttony
A compound found in red grapes called resveratrol improves the health and lifespan of mice on a high-calorie diet. This is potentially good news for overweight humans. Does it bode well for the rest of us too?
Matt Kaeberlein and Peter S. Rabinovitch
doi:10.1038/nature05308
Article: Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur, Kevin J. Pearson, Nathan L. Price, Hamish A. Jamieson, Carles Lerin, Avash Kalra, Vinayakumar V. Prabhu, Joanne S. Allard, Guillermo Lopez-Lluch, Kaitlyn Lewis, Paul J. Pistell, Suresh Poosala, Kevin G. Becker, Olivier Boss, Dana Gwinn, Mingyi Wang, Sharan Ramaswamy, Kenneth W. Fishbein, Richard G. Spencer, Edward G. Lakatta, David Le Couteur, Reuben J. Shaw, Placido Navas, Pere Puigserver, Donald K. Ingram, Rafael de Cabo and David A. Sinclair
doi:10.1038/nature05354
Abstract | Full Text | PDF (520K) | Supplementary information
