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Editorials

Another one bites the dust p123

The hazards of seeking to implement reforms at universities with outstanding reputations have been demonstrated once again, this time in Switzerland.

doi:10.1038/444123a


Correction or retraction? p123

Errors reported in this issue by authors of a Nature paper pose a dilemma about trust.

doi:10.1038/444123b


Smart but lightweight p124

An imaginative innovation policy in Britain continues to be under-resourced.

doi:10.1038/444124a


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Research Highlights

Research highlights p126

doi:10.1038/444126a


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News

Telescope is no longer dish of the day p128

Arecibo in the firing line as US observatories face cuts.

Heidi Ledford

doi:10.1038/444128a


Data handling causes image problem for top lab p129

Correction to 1993 paper gets physicists talking.

Geoff Brumfiel

doi:10.1038/444129a


It's the junk that makes us human p130

'Non-coding' DNA may organize brain cell connections.

Erika Check

doi:10.1038/444130a


Faculty forces president to quit Swiss role p130

Leading European university in turmoil.

Alison Abbott

doi:10.1038/444130b


Power up your memory bank p133

A stimulating night's sleep improves recall.

Kerri Smith

doi:10.1038/444133a


Telling the time p134

Geochronologists are pinning down dates in deep time better than ever before. Rex Dalton talks to the experts who are redrawing the details of Earth history.

doi:10.1038/444134a


Sidelines p135

doi:10.1038/444135a


News in brief p136

doi:10.1038/444136a


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Business

A breed apart p137

The US Food and Drug Administration may soon approve the use of cloned livestock for food. But regulatory roadblocks aren't the only thing keeping clones off the menu, as Heidi Ledford reports.

doi:10.1038/444137a


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News Features

Radio astronomy: Dutch courage p138

Most astronomers head for remote mountain-tops or deserts to study the cosmos. Jenny Hogan meets a confident team set up on a patch of farmland in a crowded corner of mainland Europe.

doi:10.1038/444138a


Infant pain: Does it hurt? p143

Working out whether premature babies feel pain has important implications for child development, says Jane Qiu.

doi:10.1038/444143a


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Correspondence

An open letter to Colonel Muammar al-Gaddafi p146

Richard J. Roberts and 113 fellow Nobel Laureates .

doi:10.1038/444146a


Don't forget the steps that led physics to where it is p146

Antonino Zichichi

doi:10.1038/444146b


Biodiversity definitions vary within the discipline p146

Alison Holt

doi:10.1038/444146c


US scorn for treaties hasn't improved nuclear security p146

Sebastian Raupach

doi:10.1038/444146d


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Books and Arts

One culture? p147

We can gain a clearer picture of visual representation by crossing the divide between art and science.

Bart Kahr reviews Seen | Unseen: Art, Science and Intuition from Leonardo to the Hubble Telescope by Martin Kemp

doi:10.1038/444147a

See also: Editor's summary


Exhibition: Sowing the seeds p148

Simon Mawer reviews Gregor Mendel: Planting the Seeds of Genetics

doi:10.1038/444148a


Correction p148

doi:10.1038/444148b


Exhibition: The ballerina within p149

Laura Spinney reviews Picasso XRAYS

doi:10.1038/444149a


Easing the pain p149

John Carmody reviews The Worst of Evils: The Fight Against Pain by Thomas Dormandy

doi:10.1038/444149b


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News and Views

Cell biology: A clean energy programme p151

Mitochondria supply cells with energy, but in the process produce potentially damaging oxidants. It seems that a protein required to produce new mitochondria also protects against the resulting oxidative damage.

Toren Finkel

doi:10.1038/444151a


Climate change: The south–north connection p152

A new ice-core record from Antarctica provides the best evidence yet of a link between climate in the northern and southern polar regions that operates through changes in ocean circulation.

Eric J. Steig

doi:10.1038/444152a

See also: Editor's summary


Structural biology: Enzyme theory holds water p153

Intramembrane proteases have attracted much attention because of their biological and medical value. The first crystal structure of one of these enzymes begins to solve the mystery of how they work.

Matthew Freeman

doi:10.1038/nature05305

See also: Editor's summary


Neurobiology: Right timing for retina repair p156

Transplants of photoreceptor cells offer hope for treating retinal disease. But getting the cells to make the right connections with the brain has been problematic. It seems the developmental stage of the cells may be the key.

Thomas A. Reh

doi:10.1038/444156a

See also: Editor's summary


Physiology: Channelled pain p156

Lesley Anson

doi:10.1038/444156b

See also: Editor's summary


Astronomy: A troupe of near dwarfs p158

Faint satellite galaxies of the Milky Way are being discovered that are dimmer than some of the Milky Way's star clusters. This finding poses a fundamental question: what are galaxies?

Sidney van den Bergh

doi:10.1038/444157a


50 & 100 Years Ago p159

doi:10.1038/444159b


Immunology: Exposure of an executioner p159

The complement C3 protein binds to pathogens, singling them out for execution by the immune system. Structural studies show how the chemical group responsible for this binding is exposed on activation.

Michael Carroll

doi:10.1038/nature05307


Quantum physics: Information on heat p161

There is a fundamental quantum limit to heat flow, just as there is to electric current. This limit is independent of what carries the heat, and could also have a role in an unexpected quarter: information theory.

Keith Schwab

doi:10.1038/444161a


Earth science: Isotopic hide and seek p162

Isotopes formed by the decay of radioactive nuclei provide evidence of how Earth was shaped in its infancy. But some decay products seem to be hidden — a finding that will revitalize a debate about Earth's interior.

Francis Albarède

doi:10.1038/444162a


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Brief Communications

Mechanoluminescence: Light from sonication of crystal slurries p163

Light flashes sparked by acoustic shock waves far outshine those created by manual crushing.

Nathan C. Eddingsaas and Kenneth S. Suslick

doi:10.1038/444163a


Human immunodeficiency viruses: SIV infection in wild gorillas p164

Fran Van Heuverswyn, Yingying Li, Cecile Neel, Elizabeth Bailes, Brandon F. Keele, Weimin Liu, Severin Loul, Christelle Butel, Florian Liegeois, Yanga Bienvenue, Eitel Mpoudi Ngolle, Paul M. Sharp, George M. Shaw, Eric Delaporte, Beatrice H. Hahn and Martine Peeters

doi:10.1038/444164a

See also: Editor's summary


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Articles

Great Himalayan earthquakes and the Tibetan plateau p165

Nicole Feldl and Roger Bilham

doi:10.1038/nature05199

See also: Editor's summary


Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia p171

Jean-Marc Aury, Olivier Jaillon, Laurent Duret, Benjamin Noel, Claire Jubin, Betina M. Porcel, Béatrice Ségurens, Vincent Daubin, Véronique Anthouard, Nathalie Aiach, Olivier Arnaiz, Alain Billaut, Janine Beisson, Isabelle Blanc, Khaled Bouhouche, Francisco Câmara, Sandra Duharcourt, Roderic Guigo, Delphine Gogendeau, Michael Katinka, Anne-Marie Keller, Roland Kissmehl, Catherine Klotz, France Koll, Anne Le Mouël, Gersende Lepère, Sophie Malinsky, Mariusz Nowacki, Jacek K. Nowak, Helmut Plattner, Julie Poulain, Françoise Ruiz, Vincent Serrano, Marek Zagulski, Philippe Dessen, Mireille Bétermier, Jean Weissenbach, Claude Scarpelli, Vincent Schächter, Linda Sperling, Eric Meyer, Jean Cohen and Patrick Wincker

doi:10.1038/nature05230

See also: Editor's summary


Crystal structure of a rhomboid family intramembrane protease p179

Yongcheng Wang, Yingjiu Zhang and Ya Ha

doi:10.1038/nature05255

See also: Editor's summary | News and Views by Freeman


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Letters

Lunar activity from recent gas release p184

Peter H. Schultz, Matthew I. Staid and Carlé M. Pieters

doi:10.1038/nature05303

See also: Editor's summary


Single-mode heat conduction by photons p187

Matthias Meschke, Wiebke Guichard and Jukka P. Pekola

doi:10.1038/nature05276

See also: News and Views by Schwab


Boundary lubrication under water p191

Wuge H. Briscoe, Simon Titmuss, Fredrik Tiberg, Robert K. Thomas, Duncan J. McGillivray and Jacob Klein

doi:10.1038/nature05196

See also: Editor's summary


One-to-one coupling of glacial climate variability in Greenland and Antarctica p195

EPICA Community Members and

doi:10.1038/nature05301

See also: Editor's summary | News and Views by Steig


An exceptional Devonian fish from Australia sheds light on tetrapod origins p199

John A. Long, Gavin C. Young, Tim Holland, Tim J. Senden and Erich M. G. Fitzgerald

doi:10.1038/nature05243

See also: Editor's summary


Retinal repair by transplantation of photoreceptor precursors p203

R. E. MacLaren, R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden and R. R. Ali

doi:10.1038/nature05161

See also: Editor's summary | News and Views by Reh


Spider toxins activate the capsaicin receptor to produce inflammatory pain p208

Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A. Lumpkin, Allan I. Basbaum, David King and David Julius

doi:10.1038/nature05285

See also: Editor's summary


Structure of C3b reveals conformational changes that underlie complement activity p213

Bert J. C. Janssen, Agni Christodoulidou, Andrew McCarthy, John D. Lambris and Piet Gros

doi:10.1038/nature05172

See also: Editor's summary | News and Views by Carroll


Structure of C3b in complex with CRIg gives insights into regulation of complement activation p217

Christian Wiesmann, Kenneth J. Katschke, JianPing Yin, Karim Y. Helmy, Micah Steffek, Wayne J. Fairbrother, Scott A. McCallum, Lizette Embuscado, Laura DeForge, Philip E. Hass and Menno van Lookeren Campagne

doi:10.1038/nature05263

See also: Editor's summary | News and Views by Carroll


The structure of complement C3b provides insights into complement activation and regulation p221

A. Abdul Ajees, K. Gunasekaran, John E. Volanakis, Sthanam. V. L. Narayana, Girish J. Kotwal and H. M. Krishna Murthy

doi:10.1038/nature05258

See also: Editor's summary | News and Views by Carroll


Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein p226

Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L. Brunkan-LaMontagne, Bradley R. Clarke, Chris Whitfield and James H. Naismith

doi:10.1038/nature05267

See also: Editor's summary


A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling p230

Adam Friedman and Norbert Perrimon

doi:10.1038/nature05280


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Corrigenda

Atomic-resolution chemical analysis using a scanning transmission electron microscope p235

N. D. Browning, M. F. Chisholm and S. J. Pennycook

doi:10.1038/nature05262


Earthquakes triggered by silent slip events on Kbold imacrlauea volcano, Hawaii p235

Paul Segall, Emily K. Desmarais, David Shelly, Asta Miklius and Peter Cervelli

doi:10.1038/nature05297


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Erratum

Centrosome polarization delivers secretory granules to the immunological synapse p236

Jane C. Stinchcombe, Endre Majorovits, Giovanna Bossi, Stephen Fuller and Gillian M. Griffiths

doi:10.1038/nature05299


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Naturejobs

Prospect

Prospects p237

Paul Smaglik

doi:10.1038/nj7116-137a


Special report

Closing the deal p238

Sales and marketing jobs at pharmaceutical companies offer the opportunity to combine science with social skills and creative flair. Hannah Hoag investigates the pitch.

Hannah Hoag

doi:10.1038/444238a


Career Views

Georgina Mace, director, Centre for Population Biology, Imperial College London, UK p240

Georgina Mace addresses conservation efforts as head of a population-biology centre.

Virginia Gewin

doi:10.1038/nj7116-240a


The view from Russia p240

Russian science is slowly adapting to political change.

Mikhail Gelfand

doi:10.1038/nj7116-240b


The path to a PhD p240

How I fell in love with plants on the way to a PhD.

Mhairi Dupré

doi:10.1038/nj7116-240c


Highlights

Highlight: Francophone

doi:10.1038/nj0132


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Futures

Making the sale p242

Give 'em the easy choice.

Fredric Heeren

doi:10.1038/444242a


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