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Immunology

Exposure of an executioner

The complement C3 protein binds to pathogens, singling them out for execution by the immune system. Structural studies show how the chemical group responsible for this binding is exposed on activation.

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Figure 1: Complement C3 is activated by three pathways.
Figure 2: Breakdown of complement C3.

Notes

  1. This article and the papers concerned3,4,5 were published online on 15 October 2006.

References

  1. Levashina, E. A. et al. Cell 104, 709–718 (2001).

    Article  CAS  Google Scholar 

  2. Janssen, B. J. C. et al. Nature 437, 505–511 (2005).

    Article  ADS  CAS  Google Scholar 

  3. Janssen, B. J. C., Christodoulidou, A., McCarthy, A., Lambris, J. D. & Gros, P. Nature 444, 213–216 (2006).

    Article  ADS  CAS  Google Scholar 

  4. Ajees, A. A. et al. Nature 444, 221–225 (2006).

    Article  ADS  Google Scholar 

  5. Wiesmann, C. et al. Nature 444, 217–220 (2006).

    Article  ADS  CAS  Google Scholar 

  6. Reid, K. B. & Porter, R. R. Annu. Rev. Biochem. 50, 433–464 (1981).

    Article  CAS  Google Scholar 

  7. Thiel, S. et al. Nature 386, 506–510 (1997).

    Article  ADS  CAS  Google Scholar 

  8. Farries, T. C., Lachmann, P. J. & Harrison, R. A. Biochem. J. 252, 47–54 (1988).

    Article  CAS  Google Scholar 

  9. Fearon, D. T. & Locksley, R. M. Science 272, 50–53 (1996).

    Article  ADS  CAS  Google Scholar 

  10. Pickering, M. C. et al. Nature Genet. 31, 424–428 (2002).

    Article  CAS  Google Scholar 

  11. Haines, J. L. et al. Science 308, 419–421 (2005).

    Article  ADS  CAS  Google Scholar 

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Carroll, M. Exposure of an executioner. Nature 444, 159–160 (2006). https://doi.org/10.1038/nature05307

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