Table of contents
Volume 444 Number 7116 pp123-242
Editorials
Another one bites the dust p123
The hazards of seeking to implement reforms at universities with outstanding reputations have been demonstrated once again, this time in Switzerland.
doi:10.1038/444123a
Correction or retraction? p123
Errors reported in this issue by authors of a Nature paper pose a dilemma about trust.
doi:10.1038/444123b
Smart but lightweight p124
An imaginative innovation policy in Britain continues to be under-resourced.
doi:10.1038/444124a
News
Telescope is no longer dish of the day p128
Arecibo in the firing line as US observatories face cuts.
Heidi Ledford
doi:10.1038/444128a
Data handling causes image problem for top lab p129
Correction to 1993 paper gets physicists talking.
Geoff Brumfiel
doi:10.1038/444129a
It's the junk that makes us human p130
'Non-coding' DNA may organize brain cell connections.
Erika Check
doi:10.1038/444130a
Faculty forces president to quit Swiss role p130
Leading European university in turmoil.
Alison Abbott
doi:10.1038/444130b
Power up your memory bank p133
A stimulating night's sleep improves recall.
Kerri Smith
doi:10.1038/444133a
Telling the time p134
Geochronologists are pinning down dates in deep time better than ever before. Rex Dalton talks to the experts who are redrawing the details of Earth history.
doi:10.1038/444134a
Sidelines p135
doi:10.1038/444135a
Business
A breed apart p137
The US Food and Drug Administration may soon approve the use of cloned livestock for food. But regulatory roadblocks aren't the only thing keeping clones off the menu, as Heidi Ledford reports.
doi:10.1038/444137a
News Features
Radio astronomy: Dutch courage p138
Most astronomers head for remote mountain-tops or deserts to study the cosmos. Jenny Hogan meets a confident team set up on a patch of farmland in a crowded corner of mainland Europe.
doi:10.1038/444138a
Infant pain: Does it hurt? p143
Working out whether premature babies feel pain has important implications for child development, says Jane Qiu.
doi:10.1038/444143a
Correspondence
An open letter to Colonel Muammar al-Gaddafi p146
Richard J. Roberts and 113 fellow Nobel Laureates .
doi:10.1038/444146a
Don't forget the steps that led physics to where it is p146
Antonino Zichichi
doi:10.1038/444146b
Biodiversity definitions vary within the discipline p146
Alison Holt
doi:10.1038/444146c
US scorn for treaties hasn't improved nuclear security p146
Sebastian Raupach
doi:10.1038/444146d
Books and Arts
One culture? p147
We can gain a clearer picture of visual representation by crossing the divide between art and science.
Bart Kahr reviews Seen | Unseen: Art, Science and Intuition from Leonardo to the Hubble Telescope by Martin Kemp
doi:10.1038/444147a
See also: Editor's summary
Exhibition: Sowing the seeds p148
Simon Mawer reviews Gregor Mendel: Planting the Seeds of Genetics
doi:10.1038/444148a
Correction p148
doi:10.1038/444148b
Exhibition: The ballerina within p149
Laura Spinney reviews Picasso XRAYS
doi:10.1038/444149a
Easing the pain p149
John Carmody reviews The Worst of Evils: The Fight Against Pain by Thomas Dormandy
doi:10.1038/444149b
News and Views
Cell biology: A clean energy programme p151
Mitochondria supply cells with energy, but in the process produce potentially damaging oxidants. It seems that a protein required to produce new mitochondria also protects against the resulting oxidative damage.
Toren Finkel
doi:10.1038/444151a
Climate change: The south–north connection p152
A new ice-core record from Antarctica provides the best evidence yet of a link between climate in the northern and southern polar regions that operates through changes in ocean circulation.
Eric J. Steig
doi:10.1038/444152a
See also: Editor's summary
Structural biology: Enzyme theory holds water p153
Intramembrane proteases have attracted much attention because of their biological and medical value. The first crystal structure of one of these enzymes begins to solve the mystery of how they work.
Matthew Freeman
doi:10.1038/nature05305
See also: Editor's summary
Neurobiology: Right timing for retina repair p156
Transplants of photoreceptor cells offer hope for treating retinal disease. But getting the cells to make the right connections with the brain has been problematic. It seems the developmental stage of the cells may be the key.
Thomas A. Reh
doi:10.1038/444156a
See also: Editor's summary
Physiology: Channelled pain p156
Lesley Anson
doi:10.1038/444156b
See also: Editor's summary
Astronomy: A troupe of near dwarfs p158
Faint satellite galaxies of the Milky Way are being discovered that are dimmer than some of the Milky Way's star clusters. This finding poses a fundamental question: what are galaxies?
Sidney van den Bergh
doi:10.1038/444157a
50 & 100 Years Ago p159
doi:10.1038/444159b
Immunology: Exposure of an executioner p159
The complement C3 protein binds to pathogens, singling them out for execution by the immune system. Structural studies show how the chemical group responsible for this binding is exposed on activation.
Michael Carroll
doi:10.1038/nature05307
Quantum physics: Information on heat p161
There is a fundamental quantum limit to heat flow, just as there is to electric current. This limit is independent of what carries the heat, and could also have a role in an unexpected quarter: information theory.
Keith Schwab
doi:10.1038/444161a
Earth science: Isotopic hide and seek p162
Isotopes formed by the decay of radioactive nuclei provide evidence of how Earth was shaped in its infancy. But some decay products seem to be hidden — a finding that will revitalize a debate about Earth's interior.
Francis Albarède
doi:10.1038/444162a
Brief Communications
Mechanoluminescence: Light from sonication of crystal slurries p163
Light flashes sparked by acoustic shock waves far outshine those created by manual crushing.
Nathan C. Eddingsaas and Kenneth S. Suslick
doi:10.1038/444163a
First paragraph | Full Text | PDF (205K) | Supplementary information
Human immunodeficiency viruses: SIV infection in wild gorillas p164
Fran Van Heuverswyn, Yingying Li, Cecile Neel, Elizabeth Bailes, Brandon F. Keele, Weimin Liu, Severin Loul, Christelle Butel, Florian Liegeois, Yanga Bienvenue, Eitel Mpoudi Ngolle, Paul M. Sharp, George M. Shaw, Eric Delaporte, Beatrice H. Hahn and Martine Peeters
doi:10.1038/444164a
First paragraph | Full Text | PDF (191K) | Supplementary information
See also: Editor's summary
Articles
Great Himalayan earthquakes and the Tibetan plateau p165
Nicole Feldl and Roger Bilham
doi:10.1038/nature05199
Abstract | Full Text | PDF (586K) | Supplementary information
See also: Editor's summary
Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia p171
Jean-Marc Aury, Olivier Jaillon, Laurent Duret, Benjamin Noel, Claire Jubin, Betina M. Porcel, Béatrice Ségurens, Vincent Daubin, Véronique Anthouard, Nathalie Aiach, Olivier Arnaiz, Alain Billaut, Janine Beisson, Isabelle Blanc, Khaled Bouhouche, Francisco Câmara, Sandra Duharcourt, Roderic Guigo, Delphine Gogendeau, Michael Katinka, Anne-Marie Keller, Roland Kissmehl, Catherine Klotz, France Koll, Anne Le Mouël, Gersende Lepère, Sophie Malinsky, Mariusz Nowacki, Jacek K. Nowak, Helmut Plattner, Julie Poulain, Françoise Ruiz, Vincent Serrano, Marek Zagulski, Philippe Dessen, Mireille Bétermier, Jean Weissenbach, Claude Scarpelli, Vincent Schächter, Linda Sperling, Eric Meyer, Jean Cohen and Patrick Wincker
doi:10.1038/nature05230
Abstract | Full Text | PDF (1,525K) | Supplementary information
See also: Editor's summary
Crystal structure of a rhomboid family intramembrane protease p179
Yongcheng Wang, Yingjiu Zhang and Ya Ha
doi:10.1038/nature05255
Abstract | Full Text | PDF (872K) | Supplementary information
See also: Editor's summary | News and Views by Freeman
Letters
Lunar activity from recent gas release p184
Peter H. Schultz, Matthew I. Staid and Carlé M. Pieters
doi:10.1038/nature05303
First paragraph | Full Text | PDF (596K)
See also: Editor's summary
Single-mode heat conduction by photons p187
Matthias Meschke, Wiebke Guichard and Jukka P. Pekola
doi:10.1038/nature05276
First paragraph | Full Text | PDF (361K)
See also: News and Views by Schwab
Boundary lubrication under water p191
Wuge H. Briscoe, Simon Titmuss, Fredrik Tiberg, Robert K. Thomas, Duncan J. McGillivray and Jacob Klein
doi:10.1038/nature05196
First paragraph | Full Text | PDF (345K) | Supplementary information
See also: Editor's summary
One-to-one coupling of glacial climate variability in Greenland and Antarctica p195
EPICA Community Members and
doi:10.1038/nature05301
First paragraph | Full Text | PDF (326K) | Supplementary information
See also: Editor's summary | News and Views by Steig
An exceptional Devonian fish from Australia sheds light on tetrapod origins p199
John A. Long, Gavin C. Young, Tim Holland, Tim J. Senden and Erich M. G. Fitzgerald
doi:10.1038/nature05243
First paragraph | Full Text | PDF (433K) | Supplementary information
See also: Editor's summary
Retinal repair by transplantation of photoreceptor precursors p203
R. E. MacLaren, R. A. Pearson, A. MacNeil, R. H. Douglas, T. E. Salt, M. Akimoto, A. Swaroop, J. C. Sowden and R. R. Ali
doi:10.1038/nature05161
First paragraph | Full Text | PDF (1,751K) | Supplementary information
See also: Editor's summary | News and Views by Reh
Spider toxins activate the capsaicin receptor to produce inflammatory pain p208
Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A. Lumpkin, Allan I. Basbaum, David King and David Julius
doi:10.1038/nature05285
First paragraph | Full Text | PDF (624K) | Supplementary information
See also: Editor's summary
Structure of C3b reveals conformational changes that underlie complement activity p213
Bert J. C. Janssen, Agni Christodoulidou, Andrew McCarthy, John D. Lambris and Piet Gros
doi:10.1038/nature05172
First paragraph | Full Text | PDF (762K) | Supplementary information
See also: Editor's summary | News and Views by Carroll
Structure of C3b in complex with CRIg gives insights into regulation of complement activation p217
Christian Wiesmann, Kenneth J. Katschke, JianPing Yin, Karim Y. Helmy, Micah Steffek, Wayne J. Fairbrother, Scott A. McCallum, Lizette Embuscado, Laura DeForge, Philip E. Hass and Menno van Lookeren Campagne
doi:10.1038/nature05263
First paragraph | Full Text | PDF (926K) | Supplementary information
See also: Editor's summary | News and Views by Carroll
The structure of complement C3b provides insights into complement activation and regulation p221
A. Abdul Ajees, K. Gunasekaran, John E. Volanakis, Sthanam. V. L. Narayana, Girish J. Kotwal and H. M. Krishna Murthy
doi:10.1038/nature05258
First paragraph | Full Text | PDF (465K) | Supplementary information
See also: Editor's summary | News and Views by Carroll
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein p226
Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L. Brunkan-LaMontagne, Bradley R. Clarke, Chris Whitfield and James H. Naismith
doi:10.1038/nature05267
First paragraph | Full Text | PDF (690K) | Supplementary information
See also: Editor's summary
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling p230
Adam Friedman and Norbert Perrimon
doi:10.1038/nature05280
First paragraph | Full Text | PDF (585K) | Supplementary information
Corrigenda
Atomic-resolution chemical analysis using a scanning transmission electron microscope p235
N. D. Browning, M. F. Chisholm and S. J. Pennycook
doi:10.1038/nature05262
Earthquakes triggered by silent slip events on K
lauea volcano, Hawaii p235
Paul Segall, Emily K. Desmarais, David Shelly, Asta Miklius and Peter Cervelli
doi:10.1038/nature05297
Erratum
Centrosome polarization delivers secretory granules to the immunological synapse p236
Jane C. Stinchcombe, Endre Majorovits, Giovanna Bossi, Stephen Fuller and Gillian M. Griffiths
doi:10.1038/nature05299
Naturejobs
ProspectProspects p237
Paul Smaglik
doi:10.1038/nj7116-137a
Special report
Closing the deal p238
Sales and marketing jobs at pharmaceutical companies offer the opportunity to combine science with social skills and creative flair. Hannah Hoag investigates the pitch.
Hannah Hoag
doi:10.1038/444238a
Career Views
Georgina Mace, director, Centre for Population Biology, Imperial College London, UK p240
Georgina Mace addresses conservation efforts as head of a population-biology centre.
Virginia Gewin
doi:10.1038/nj7116-240a
The view from Russia p240
Russian science is slowly adapting to political change.
Mikhail Gelfand
doi:10.1038/nj7116-240b
The path to a PhD p240
How I fell in love with plants on the way to a PhD.
Mhairi Dupré
doi:10.1038/nj7116-240c
Highlights
Highlight: Francophone
doi:10.1038/nj0132
