The mutations that cause retinoblastoma are well known, but how they enable the cancer to evade controls on cell division was unclear. Secondary mutations affecting a growth-regulatory pathway have now been identified.
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Wallace, V. Second step to retinal tumours. Nature 444, 45–46 (2006). https://doi.org/10.1038/444045a
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DOI: https://doi.org/10.1038/444045a