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Nature 443, 998-1002 (26 October 2006) | doi:10.1038/nature05245;
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Gastroenterologist
- Gastrointestinal Diseases Inc.
- Georgia, USA
Associate Professor or Full Professor
- South Dakota State University
- Brookings, SD
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
A large amount of chromosomal DNA is degraded during programmed cell death and definitive erythropoiesis. DNase|[thinsp]|II is an enzyme that digests the chromosomal DNA of apoptotic cells and nuclei expelled from erythroid precursor cells after macrophages have engulfed them.
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