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Nature 443, 1019 (26 October 2006) | doi:10.1038/4431019a; Published online 25 October 2006

Open Innovation Challenges

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Thinking big, seeing small

Most optical imaging techniques are subject to the tyranny of the diffraction limit, where the optical properties of conventional objective lenses make it impossible to distinguish two objects separated by less than 180 nanometres in the focal plane.But limits were made to be broken.

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