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Nature 443, 796-802 (19 October 2006) | doi:10.1038/nature05293; Published online 18 October 2006
Cell death in the nervous system
Dale E. Bredesen1,2, Rammohan V. Rao1 & Patrick Mehlen1,3
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Abstract
Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease trigger neuronal cell death through endogenous suicide pathways. Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets.
- Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA.
- University of California, San Francisco, 450 Parnassus, San Francisco, California 94143, USA.
- Apoptosis, Cancer and Development Laboratory, Université de Lyon, Centre Léon Bérard, 28 Rue Laennee, 69008 Lyon, France.
Correspondence to: Dale E. Bredesen1,2 Email: dbredesen@buckinstitute.org
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