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Nature 443, 646-647 (12 October 2006) | doi:10.1038/443646a; Published online 11 October 2006

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Cell biology: Mitochondria shape up

Barbara Conradt1

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Mitochondria are central to the process of programmed cell death that kills damaged or superfluous cells. Surprisingly, components of the death machinery turn out to be essential for keeping these organelles in shape.

Proteins of the Bcl-2 family are evolutionarily conserved regulators of programmed cell death (apoptosis). However, their mechanisms of action are still not fully resolved1, 2.

  1. Barbara Conradt is in the Department of Genetics, Dartmouth Medical School, 7400 Remsen, Hanover, New Hampshire 03755, USA.
    Email: barbara.conradt@dartmouth.edu

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