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Nature 443, 629-631 (12 October 2006) | doi:10.1038/443629a; Published online 11 October 2006

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Depression: Comfortably numb

Erika Check1

  1. Erika Check is a reporter for Nature in San Francisco.

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It started life as an anaesthetic, then became a psychedelic club drug. Now researchers think ketamine could hold the key to understanding and treating depression, says Erika Check.

B held my hand and we started our roller coaster out... I can't feel my body anymore except this overriding general fuzziness. The lines on the ceiling become a tunnel and I am flying down it faster than sound... Then the room does a somersault and I with it... I'm scared... this is a thrill ride and the car is the dimensions of existence.

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