Table of contents
Volume 443 Number 7112 pp605-722
Editorials
A global folly p605
If not a global non-nuclear proliferation regime based on international treaties, then what?
doi:10.1038/443605a
Forgotten plights p605
Scientists' human-rights groups deserve stronger backing.
doi:10.1038/443605b
Ambassador for Earth p606
Is it time for SETI to reach out to the stars?
doi:10.1038/443606a
News
The fizzle heard around the world p610
North Korea's nuclear test raises more questions than answers. Despite the small size of the blast, Jim Giles and Geoff Brumfiel get little reassurance from the weapon watchers.
doi:10.1038/443610a
Protests mount against Libyan trial p612
Support grows for accused medics.
Declan Butler
doi:10.1038/443612a
Nobel prize blurs boundaries p615
"But is it chemistry?" ask chemists.
Katharine Sanderson
doi:10.1038/443615a
Intelligent design gets political p615
Teaching creationism becomes an election issue in Michigan.
Geoff Brumfiel
doi:10.1038/443615b
Sidelines p616
doi:10.1038/443616a
Hard-hitting endeavour captures Ig Nobel p616
Woodpecker research flies away with alternative prize.
Steve Nadis
doi:10.1038/443616b
News in brief p618
doi:10.1038/443618a
Correction p619
doi:10.1038/443619a
Business
Hell on no wheels p621
The crash of a demonstration train in Germany casts a shadow on magnetic levitation technology. Ned Stafford reports.
doi:10.1038/443621a
News Features
Oceanography: The real sea change p622
What can pirates' journals and centuries-old cookbooks teach modern-day ecologists? Mark Schrope meets the researchers who trawl history books for deeper insights into marine ecosystems.
doi:10.1038/443622a
See also: Editor's summary
AIDS in Africa: A question of trust p626
AIDS treatment in South Africa is often a tug-of-war between clinicians and traditional healers. Natasha Bolognesi meets a woman who is uniquely qualified to heal the rift.
doi:10.1038/443626a
Depression: Comfortably numb p629
It started life as an anaesthetic, then became a psychedelic club drug. Now researchers think ketamine could hold the key to understanding and treating depression, says Erika Check.
doi:10.1038/443629a
See also: Editor's summary
Correspondence
Biochemistry has outgrown its traditional boundaries p632
Chris Kirk
doi:10.1038/443632a
Videos have starring role to play in protocol sharing p632
Matias Pasquali
doi:10.1038/443632b
Consistency tests establish empirical generalizations p632
Brian D. Haig
doi:10.1038/443632c
Chimp comparisons won't explain human evolution p632
Robert Barton
doi:10.1038/443632d
Science prediction rate would be good in gambling p632
Kenneth D. Pimple
doi:10.1038/443632e
Books and Arts
Evolution's highest branches p633
An intriguing tour around and, especially, up the tree of life.
Matthew A. Wills reviews Creatures of Accident: The Rise of the Animal Kingdom by Wallace Arthur
doi:10.1038/443633a
Psychoneuroindoctrinology p634
Rebecca M. Young and Evan Balaban review The Female Brain by Louann Brizendine
doi:10.1038/443634a
A comprehensive medical history p635
Andreas-Holger Maehle reviews The Western Medical Tradition: 1800 to 2000 by W. F. Bynum, Anne Hardy, Stephen Jacyna, Christopher Lawrence and E. M. (Tilli) Tansey
doi:10.1038/443635a
The background buzz p635
P. V. E. McClintock reviews Noise by Bart Kosko
doi:10.1038/443635b
Science in culture: A modern megalith p636
Mariko Mori's glass sculpture responds to the death of stars.
Martin Kemp
doi:10.1038/443636a
See also: Editor's summary
News and Views
Particle physics: Did the big bang boil? p637
Standard theories tell us that, at some point in the Universe's evolution, free quarks and gluons must have become bound together into the hadronic matter we see today. But was this transition abrupt or smooth?
Frank Wilczek
doi:10.1038/443637a
See also: Editor's summary
Evolutionary biology: Fly eyes get the whole picture p638
The compound eyes of ancestral flies picked up only one picture point in each facet. The evolution of a means to split up the light-sensitive cells increased this number to seven, boosting the eye's resolution greatly.
Kevin Moses
doi:10.1038/nature05209
See also: Editor's summary
50 & 100 years ago p639
doi:10.1038/443639a
Physical chemistry: Seeds of phase change p641
An effective but counter-intuitive trick to obtain highly ordered protein crystals is to 'seed' particles on disordered, porous surfaces. Computer simulations provide an explanation for the success of this strategy.
Daan Frenkel
doi:10.1038/443641a
Neuroscience: Controlled capillaries p642
The finest scale of blood flow through the brain occurs in capillaries. Suspicions that capillary flow is regulated by cells that put the squeeze on these vessels are now borne out by detailed experiments.
Brian A. MacVicar and Michael W. Salter
doi:10.1038/443642a
See also: Editor's summary
Developmental biology: A change of heart p642
Helen Dell
doi:10.1038/443642b
Earth sciences: Ups and downs of ancient oxygen p643
The latest models suggest that atmospheric oxygen could have fluctuated between high and low concentrations once photosynthesis had evolved. But does the geological evidence really support this?
James F. Kasting
doi:10.1038/443643a
See also: Editor's summary
Ecology: Moving to the ideal free home p645
Pike move between two basins of a British lake to maximize their evolutionary fitness. This adaptive behaviour suggests that habitat selection is more significant in population dynamics than was thought.
Douglas W. Morris
doi:10.1038/443645a
Cell biology: Mitochondria shape up p646
Mitochondria are central to the process of programmed cell death that kills damaged or superfluous cells. Surprisingly, components of the death machinery turn out to be essential for keeping these organelles in shape.
Barbara Conradt
doi:10.1038/443646a
See also: Editor's summary
Brief Communications
An accessory chromophore in red vision p649
The rods in salamanders' retinas can co-opt a molecule derived from chlorophyll to detect red light.
T. Isayama, D. Alexeev, C. L. Makino, I. Washington, K. Nakanishi and N. J. Turro
doi:10.1038/443649a
First paragraph | Full Text | PDF (177K) | Supplementary information
Corrigendum p649
doi:10.1038/443649b
Review
Phosphoinositides in cell regulation and membrane dynamics p651
Gilbert Di Paolo and Pietro De Camilli
doi:10.1038/nature05185
Abstract | Full Text | PDF (2,478K)
Articles
Role of Bax and Bak in mitochondrial morphogenesis p658
Mariusz Karbowski, Kristi L. Norris, Megan M. Cleland, Seon-Yong Jeong and Richard J. Youle
doi:10.1038/nature05111
Abstract | Full Text | PDF (684K) | Supplementary information
Structure of eEF3 and the mechanism of transfer RNA release from the E-site p663
Christian B. F. Andersen, Thomas Becker, Michael Blau, Monika Anand, Mario Halic, Bharvi Balar, Thorsten Mielke, Thomas Boesen, Jan Skov Pedersen, Christian M. T. Spahn, Terri Goss Kinzy, Gregers R. Andersen and Roland Beckmann
doi:10.1038/nature05126
Abstract | Full Text | PDF (573K) | Supplementary information
See also: Editor's summary
Letters
The sequestration of ethane on Titan in smog particles p669
D. M. Hunten
doi:10.1038/nature05157
First paragraph | Full Text | PDF (77K)
See also: Editor's summary
Observation of strong coupling between one atom and a monolithic microresonator p671
Takao Aoki, Barak Dayan, E. Wilcut, W. P. Bowen, A. S. Parkins, T. J. Kippenberg, K. J. Vahala and H. J. Kimble
doi:10.1038/nature05147
First paragraph | Full Text | PDF (316K) | Supplementary information
The order of the quantum chromodynamics transition predicted by the standard model of particle physics p675
Y. Aoki,
G. Endr
di,
Z. Fodor,
S. D. Katz
and
K. K. Szabó
doi:10.1038/nature05120
First paragraph | Full Text | PDF (228K)
See also: Editor's summary
Origin of the dielectric dead layer in nanoscale capacitors p679
Massimiliano Stengel and Nicola A. Spaldin
doi:10.1038/nature05148
First paragraph | Full Text | PDF (272K)
Bistability of atmospheric oxygen and the Great Oxidation p683
Colin Goldblatt, Timothy M. Lenton and Andrew J. Watson
doi:10.1038/nature05169
First paragraph | Full Text | PDF (335K) | Supplementary information
See also: Editor's summary
Long-period astronomical forcing of mammal turnover p687
Jan A. van Dam, Hayfaa Abdul Aziz, M. Ángeles Álvarez Sierra, Frederik J. Hilgen, Lars W. van den Hoek Ostende, Lucas J. Lourens, Pierre Mein, Albert J. van der Meulen and Pablo Pelaez-Campomanes
doi:10.1038/nature05163
First paragraph | Full Text | PDF (409K) | Supplementary information
See also: Editor's summary
Low-coverage vaccination strategies for the conservation of endangered species p692
D. T. Haydon, D. A. Randall, L. Matthews, D. L. Knobel, L. A. Tallents, M. B. Gravenor, S. D. Williams, J. P. Pollinger, S. Cleaveland, M. E. J. Woolhouse, C. Sillero-Zubiri, J. Marino, D. W. Macdonald and M. K. Laurenson
doi:10.1038/nature05177
First paragraph | Full Text | PDF (331K) | Supplementary information
See also: Editor's summary
Transforming the architecture of compound eyes p696
Andrew C. Zelhof, Robert W. Hardy, Ann Becker and Charles S. Zuker
doi:10.1038/nature05128
First paragraph | Full Text | PDF (488K) | Supplementary information
See also: Editor's summary
Bidirectional control of CNS capillary diameter by pericytes p700
Claire M. Peppiatt, Clare Howarth, Peter Mobbs and David Attwell
doi:10.1038/nature05193
First paragraph | Full Text | PDF (1,742K) | Supplementary information
See also: Editor's summary
Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors p705
Andrés E. Chávez, Joshua H. Singer and Jeffrey S. Diamond
doi:10.1038/nature05123
First paragraph | Full Text | PDF (1,188K) | Supplementary information
Identification of nesfatin-1 as a satiety molecule in the hypothalamus p709
Shinsuke Oh-I, Hiroyuki Shimizu, Tetsurou Satoh, Shuichi Okada, Sachika Adachi, Kinji Inoue, Hiroshi Eguchi, Masanori Yamamoto, Toshihiro Imaki, Koushi Hashimoto, Takafumi Tsuchiya, Tsuyoshi Monden, Kazuhiko Horiguchi, Masanobu Yamada and Masatomo Mori
doi:10.1038/nature05162
First paragraph | Full Text | PDF (338K) | Supplementary information
See also: Editor's summary
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates p713
Ivan Ahel, Ulrich Rass, Sherif F. El-Khamisy, Sachin Katyal, Paula M. Clements, Peter J. McKinnon, Keith W. Caldecott and Stephen C. West
doi:10.1038/nature05164
First paragraph | Full Text | PDF (476K) | Supplementary information
Addendum
Sustainability of three apple production systems p717
John P. Reganold, Jerry D. Glover, Preston K. Andrews and Herbert R. Hinman
doi:10.1038/nature05188
Full Text | PDF (45K) | Supplementary information
Corrigendum
Structure of the E. coli protein-conducting channel bound to a translating ribosome p718
Kakoli Mitra, Christiane Schaffitzel, Tanvir Shaikh, Florence Tama, Simon Jenni, Charles L. Brooks, Nenad Ban and Joachim Frank
doi:10.1038/nature05086
Naturejobs
ProspectProspects p719
Adaptability can trump planning in career considerations.
Paul Smaglik
doi:10.1038/nj7112-719a
Career Views
King Holmes, director, Department of Global Health, University of Washington, Seattle p720
New public health challenges for King Holmes at the University of Washington.
Virginia Gewin
doi:10.1038/nj7112-720a
More than one route to PhD success p720
Two researchers offer their take on how to succeed as a PhD student.
Sarah Bekessy & Brendan Wintle
doi:10.1038/nj7112-720b
Lab life or love life? p720
Sometimes dedication in the lab leaves little time for personal relationships.
Mhairi Dupré
doi:10.1038/nj7112-720c
Futures
Picasso's cat p722
The editor's wavefunction collapses.
Ron Collins
doi:10.1038/443722a