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Nature 443, 574-577 (27 September 2006) | doi:10.1038/nature05133;
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Functional epistasis on a common MHC haplotype associated with multiple sclerosis
Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in strong linkage disequilibrium; however, little is known about the mechanisms responsible for this linkage disequilibrium.
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