The proliferation of cells must balance the longevity assured by tissue renewal against the risk of developing cancer. The tumour-suppressor protein p16INK4a seems to act at the pivot of this delicate equilibrium.
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Beausejour, C., Campisi, J. Balancing regeneration and cancer. Nature 443, 404–405 (2006). https://doi.org/10.1038/nature05221
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DOI: https://doi.org/10.1038/nature05221