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Nature 443, 382 (28 September 2006) | doi:10.1038/443382a; Published online 27 September 2006

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'Big science' protein project under fire

David Cyranoski

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Critics question results as Protein 3000 winds down

It was to have been a giant step towards understanding the many different ways in which a protein can fold. That knowledge would enable one to predict the characteristic structure of any given protein from its gene sequence — a critical tool for understanding how proteins interact and for developing effective drugs.

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