PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

doi:doi:10.1038/nature05115

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman and Bruce D. Walker

Nature 443, 350-354(21 September 2006)

doi:10.1038/nature05115

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Supplementary Notes

This file contains Supplementary Figures 1–4 and Supplementary Table 1. These figures provide supporting data indicating that PD-1 expression is associated with functional impairment of HIV-specific CD8 T cells, and that PD-1 expression on HIV-specific CD8 T cells and total CD8 T cells is associated with viral load and absolute CD4 count. Supplementary Table 1 lists the MHC Class I tetramers used in this study.

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