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Nature 443, 350-354 (20 August 2006) | doi:10.1038/nature05115;
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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Functional impairment of T cells is characteristic of many chronic mouse and human viral infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a negative regulator of activated T cells, is markedly upregulated on the surface of exhausted virus-specific CD8 T cells in mice.
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