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Nature 443, 258-259 (21 September 2006) | doi:10.1038/443258a; Published online 20 September 2006

Sequencers step up to the speed challenge

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In future, hospitals should be able to sequence patient DNA swiftly and cheaply. Rex Dalton reports on the firms bringing that day closer.

In the summer of 1999, Jonathan Rothberg was nervously distracting himself by flipping through a computer magazine as he waited to find out whether his newborn son would survive a medical crisis. A headline about a computer chip with 44 million transistors leapt off the page; Rothberg, a chemical engineer, immediately asked himself whether some similar sort of miniaturization might one day make it easy to screen the genome of a sick child and swiftly reveal the nature of his or her illness.