Perseverance yields the discovery of an infant hominin skeleton.
doi:10.1038/7109xiiia
Table of contents
Volume 443 Number 7109 ppxiii-370
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Top of page
Authors
Making the paper: Zeresenay Alemseged pxiii
Abstractions pxiii
doi:10.1038/7109xiiib
Key collaborations pxiii
doi:10.1038/7109xiiic
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Editorials
An ailing agency p245
Public health needs strong advocacy within government — and Congress should make sure that the US Centers for Disease Control and Prevention continues to provide it.
doi:10.1038/443245a
Libya's travesty p245
Six medical workers in Libya face execution. It is not too late for scientists to speak up on their behalf.
doi:10.1038/443245b
The brief goodbye p246
Because of trends in submissions, Nature's Brief Communications will bow out at the end of the year.
doi:10.1038/443246a
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News
Claims of brain drain follow CDC reshuffle p250
Health agency backs use of DDT against malaria p250
Much-maligned pesticide returns to the front line.
Apoorva Mandavilli
doi:10.1038/443250b
Agency accused of 'illusion of integrity' p252
NIH grilled over handling of ethics breaches.
Meredith Wadman
doi:10.1038/443252a
Mystery surrounds lab death p253
Japanese biologist found poisoned at his bench.
Ichiko Fuyuno and David Cyranoski
doi:10.1038/443253a
Sidelines p254
doi:10.1038/443254a
Lawyers call for science to clear AIDS nurses in Libya p254
International pressure needed to save health workers from death penalty.
Declan Butler
doi:10.1038/443254b
Snapshot: Idol scans p256
That's no laser, it's a particle accelerator p256
Device mimics light source to speed up electrons.
Geoff Brumfiel
doi:10.1038/443256b
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Business
Sequencers step up to the speed challenge p258
In future, hospitals should be able to sequence patient DNA swiftly and cheaply. Rex Dalton reports on the firms bringing that day closer.
doi:10.1038/443258a
In brief p259
doi:10.1038/443259a
Market watch p259
doi:10.1038/443259b
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News Features
Medicine: Sleep it off p261
We've been told to eat less and move more to battle the growing obesity epidemic. But could getting more shuteye also be a way to fight the fat? Helen Pearson investigates.
Helen Pearson
doi:10.1038/443261a
Environmental science: A testing experience p265
Interdisciplinary research is the new buzzword, but does a grounding in different disciplines really make you better at solving problems? Amanda Haag joins an experiment to find out.
Amanda Haag
doi:10.1038/443265a
Palaeoanthropology: The history man p268
Maurice Taieb laid the groundwork for the discovery of Lucy, the most famous fossil human ancestor. Rex Dalton meets the Tunisian-born geologist who prefers the desert to the limelight.
Rex Dalton
doi:10.1038/443268a
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Correspondence
Freedom of the mind got Nature banned by the Nazis p271
feld
and
Lennart OlssonIran: support for science does not outweigh crimes p271
Iran is sixth, not second, in Middle East publication list p271
Iran's progress towards nuclear capability is no joke p271
Taking time to savour the rewards of slow science p271
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Books and Arts
The road to hell? p273
The good intentions of a leading ecologist may not be enough to save Earth's biodiversity.
doi:10.1038/443273a
Teeming boisterous life p274
doi:10.1038/443274a
Astronomy through the years p274
doi:10.1038/443274b
Failing the ailing p275
doi:10.1038/443275a
Science in Culture: A miracle in sight p276
Adam Elsheimer painted the starry heavens in 1609.
Martin Kemp
doi:10.1038/443276a
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News and Views
気候変動：グリーンランドの氷を量る
Climate change: Greenland's ice on the scales p277
Satellite measurements of changes in Earth's gravity field reveal ice loss from Greenland's ice sheet. Over the past four years, this melt has contributed to global sea-level rise at an accelerating rate.
Tavi Murray
doi:10.1038/443277a
日本語要約 | Full Text | PDF (384K)
古人類学：貴重な赤ん坊
Palaeoanthropology: A precious little bundle p278
The three-million-year old skeleton of a three-year-old child provides an outstanding resource to understand the development of a human ancestor that seems to have both walked upright and climbed through trees.
Bernard Wood
doi:10.1038/443278a
日本語要約 | Full Text | PDF (499K)
50 & 100 years ago p279
doi:10.1038/443279a
日本語要約 | Full Text | PDF (152K)
数理物理学：探索の研究
Mathematical physics: Search research p281
How does one best search for non-replenishable targets at unknown positions? An optimized search strategy could be applied to situations as diverse as animal foraging and time-sensitive rescue missions.
Michael F. Shlesinger
doi:10.1038/443281a
日本語要約 | Full Text | PDF (346K)
HIV：疲弊したT細胞の元気回復法
HIV: Tired T cells turn around p282
HIV-1 prompts a massive cellular immune response, but eventually it tires the immune cells. Blocking the activation of a cell receptor called PD-1 might restore these exhausted cells.
Sarah Rowland-Jones and Tao Dong
doi:10.1038/443282a
日本語要約 | Full Text | PDF (216K)
天文学：すてきな超新星
Astronomy: Champagne supernova p283
Thermonuclear supernovae were thought to occur only when white-dwarf stars of a certain mass explode. The discovery of a supernova that is way over the mass limit might require a reworking of the model.
David Branch
doi:10.1038/443283a
日本語要約 | Full Text | PDF (438K)
幹細胞：若返りへの新しい道
Stem cells: A new route to rejuvenation p284
Embryonic stem cells are prized for their ability to mature into all the specialized adult cell types. It may now be possible to reprogramme adult body cells to have the characteristics of stem cells.
M. Azim Surani and Anne McLaren
doi:10.1038/443284a
日本語要約 | Full Text | PDF (440K)
化学生物学：やさしい交換
Chemical biology: A sweet exchange p285
Many drugs isolated from microorganisms have complex molecular structures, making it difficult for chemists to modify them. But it seems that enzymes can provide a short cut to drug variants.
Christopher T. Walsh
doi:10.1038/443285a
日本語要約 | Full Text | PDF (177K)
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Top of page
Brief Communications
Induction of an illusory shadow person p287
Shahar Arzy, Margitta Seeck, Stephanie Ortigue, Laurent Spinelli and Olaf Blanke
doi:10.1038/443287a
First paragraph | Full Text | PDF (193K) | Supplementary information
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Brief Communications Arising
Gene therapy: Is IL2RG oncogenic in T-cell development? pE5
Karin Pike-Overzet, Dick de Ridder, Floor Weerkamp, Miranda R. M. Baert, Monique M. Verstegen, Martijn H. Brugman, Steven J. Howe, Marcel J. T. Reinders, Adrian J. Thrasher, Gerard Wagemaker, Jacques J. M. van Dongen and Frank J. T. Staal
doi:10.1038/nature05218
Gene therapy: X-SCID transgene leukaemogenicity pE5
Adrian J. Thrasher, H. Bobby Gaspar, Christopher Baum, Ute Modlich, Axel Schambach, Fabio Candotti, Makoto Otsu, Brian Sorrentino, Linda Scobie, Ewan Cameron, Karen Blyth, Jim Neil, Salima Hacein-Bey Abina, Marina Cavazzana-Calvo and Alain Fischer
doi:10.1038/nature05219
Gene therapy: Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply) pE6
Niels-Bjarne Woods, Virginie Bottero, Manfred Schmidt, Christof von Kalle and Inder M. Verma
doi:10.1038/nature05220
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Review
医学：中枢神経系による摂食量と体重の制御
Central nervous system control of food intake and body weight p289
G. J. Morton, D. E. Cummings, D. G. Baskin, G. S. Barsh and M. W. Schwartz
doi:10.1038/nature05026
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Articles
進化：エチオピアのDikikaで出土した初期人類の幼若個体の骨格
A juvenile early hominin skeleton from Dikika, Ethiopia p296
Zeresenay Alemseged, Fred Spoor, William H. Kimbel, René Bobe, Denis Geraads, Denné Reed and Jonathan G. Wynn
doi:10.1038/nature05047
細胞：H/ACAボックスリボ核タンパク質粒子の結晶構造
Crystal structure of an H/ACA box ribonucleoprotein particle p302
Ling Li and Keqiong Ye
doi:10.1038/nature05151
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Calcineurin/NFAT signalling regulates pancreatic
Letters
宇宙：超チャンドラセカール質量の白色矮星に由来するIa型超新星SNLS-03D3bb
The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-mass white dwarf star p308
D. Andrew Howell, Mark Sullivan, Peter E. Nugent, Richard S. Ellis, Alexander J. Conley, Damien Le Borgne, Raymond G. Carlberg, Julien Guy, David Balam, Stephane Basa, Dominique Fouchez, Isobel M. Hook, Eric Y. Hsiao, James D. Neill, Reynald Pain, Kathryn M. Perrett and Christopher J. Pritchet
doi:10.1038/nature05103
物理：クエンチした強磁性スピノルボーズ・アインシュタイン凝縮体における自発的な対称性の破れ
Spontaneous symmetry breaking in a quenched ferromagnetic spinor Bose–Einstein condensate p312
L. E. Sadler, J. M. Higbie, S. R. Leslie, M. Vengalattore and D. M. Stamper-Kurn
doi:10.1038/nature05094
日本語要約 | Full Text | PDF (415K)
物理：量子計量用の「デザイナー原子」
'Designer atoms' for quantum metrology p316
C. F. Roos, M. Chwalla, K. Kim, M. Riebe and R. Blatt
doi:10.1038/nature05101
日本語要約 | Full Text | PDF (278K)
材料：ゲストフリー構造をもつゲルマニウムクラスレート
A guest-free germanium clathrate p320
Arnold M. Guloy, Reiner Ramlau, Zhongjia Tang, Walter Schnelle, Michael Baitinger and Yuri Grin
doi:10.1038/nature05145
気候：太平洋エルニーニョと「大西洋エルニーニョ」の間の関連性が不安定である原因
The cause of the fragile relationship between the Pacific El Niño and the Atlantic Niño p324
Ping Chang, Yue Fang, R. Saravanan, Link Ji and Howard Seidel
doi:10.1038/nature05053
気候：2004年春季におけるグリーンランド氷床の氷質量減少の加速
Acceleration of Greenland ice mass loss in spring 2004 p329
進化：エチオピアのDikikaにおいて鮮新世の人類の幼若個体が置かれていた地質学的・古生物学的な状況
Geological and palaeontological context of a Pliocene juvenile hominin at Dikika, Ethiopia p332
Jonathan G. Wynn, Zeresenay Alemseged, René Bobe, Denis Geraads, Denné Reed and Diana C. Roman
doi:10.1038/nature05048
日本語要約 | Full Text | PDF (1,139K) | Supplementary information
発生：ゼブラフィッシュ原腸胚における造血系と内皮系に共通する前駆細胞
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula p337
Kevin M. Vogeli, Suk-Won Jin, Gail R. Martin and Didier Y. R. Stainier
doi:10.1038/nature05045
日本語要約 | Full Text | PDF (302K)
医学：紫外線が誘発する日焼けにおけるMc1rの役割を基にした局所投与薬による救済戦略と皮膚の保護
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning p340
John A. D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R. Granter, Emi K. Nishimura, Shosuke Ito and David E. Fisher
doi:10.1038/nature05098
細胞：カルシニューリン/NFATシグナル伝達は膵β細胞の増殖と機能を調節する
Calcineurin/NFAT signalling regulates pancreatic 
-cell growth and function p345
Jeremy J. Heit, Åsa A. Apelqvist, Xueying Gu, Monte M. Winslow, Joel R. Neilson, Gerald R. Crabtree and Seung K. Kim
doi:10.1038/nature05097
医学：HIV特異的T細胞でのPD-1の発現はT細胞の疲弊と病気の進行に関係する
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression p350
Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman and Bruce D. Walker
doi:10.1038/nature05115
細胞：機能中の1個の膜タンパク質複合体の化学量論と代謝回転
Stoichiometry and turnover in single, functioning membrane protein complexes p355
Mark C. Leake, Jennifer H. Chandler, George H. Wadhams, Fan Bai, Richard M. Berry and Judith P. Armitage
doi:10.1038/nature05135
細胞：ショウジョウバエでのRNA干渉スクリーニングにおけるオフターゲット効果の起こる頻度
Prevalence of off-target effects in Drosophila RNA interference screens p359
Yong Ma, Adrian Creanga, Lawrence Lum and Philip A. Beachy
doi:10.1038/nature05179
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Career Views
Spotlight
Naturejobs
ProspectProspects p365
Paul Smaglik
doi:10.1038/nj7109-365a
Region
Up and coming p366
Beyond the urban chaos of New York City lies a tranquil state with abundant career opportunities, says Ricki Lewis.
Ricki Lewis
doi:10.1038/nj7109-366a
Career Views
Arthur Ellis, vice-chancellor for research, University of California, San Diego p368
Virginia Gewin
doi:10.1038/nj7109-368a
The mouse house p368
Hannah Hoag
doi:10.1038/nj7109-368b
Farewell to the hive p368
Katja Bargum
doi:10.1038/nj7109-368c
Spotlight
Spotlight on Upstate New York
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