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Review
Nature 443, 289-295 (21 September 2006) | doi:10.1038/nature05026
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Academic Surgical Pathologist
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Scientist in Bioinformatics
- Philip Morris International (PMI)
- Neuchatel, Switzerland
Central nervous system control of food intake and body weight
G. J. Morton1, D. E. Cummings2, D. G. Baskin2,3, G. S. Barsh4 & M. W. Schwartz1
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
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