Figures and Tables
From the following article:
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
Rupert J. Russell, Lesley F. Haire, David J. Stevens, Patrick J. Collins, Yi Pu Lin, G. Michael Blackburn, Alan J. Hay, Steven J. Gamblin and John J. Skehel
Nature 443, 45-49(7 September 2006)
doi:10.1038/nature05114
Figure 1
Genetic and structural relationships between neuraminidases from different influenza viruses.
Full size figure and legend (50K)
Figure 2
Molecular surfaces of group-1 and group-2 neuraminidases with bound oseltamivir showing the 150-cavity in the group-1 structure that arises because of the distinct conformation of the 150-loop.
Full size figure and legend (81K)
Figure 3
Oseltamivir binding to the active sites of group-1 neuraminidases.
Full size figure and legend (33K)
Figure 4
Locations of the oseltamivir resistance mutations found in group-1 and group-2 neuraminidases.
Full size figure and legend (77K)