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Nature 442, 877-878 (24 August 2006) | doi:10.1038/nature04999; Published online 23 August 2006
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Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Tier II Canada Research Chair in Cellular Science and Human Health
- Concordia University
- Montreal, Quebec Canada
Physiology: Nitrate at the ion exchange
Julian I. Schroeder1
Abstract
The distinction between CLC ion channels and ion exchangers has become blurred. The physiological role of CLC exchangers has been a mystery, but one function is evidently to concentrate nitrate in plant vacuoles.
The cell membranes of all self-respecting cells contain ion channels that allow the selective flow of, for example, sodium or potassium, or anions such as chloride, into and out of the cell. Only a couple of years ago, a startling discovery was made that certain predicted chloride channels — specifically, members of the CLC family — function not as passive chloride-selective ion channels, but as proton–chloride exchangers that transport protons and chloride anions in opposite directions across cell membranes1, 2, 3.
- Julian I. Schroeder is in the Division of Biological Sciences, Cell and Developmental Biology Section, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0116, USA.
Email: julian@biomail.ucsd.edu
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RESEARCH
The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuolesNature Letters to Editor (24 Aug 2006)
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