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Nature 442, 874-875 (24 August 2006) | doi:10.1038/442874a; Published online 23 August 2006
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Cell biology: A licence for duplication
Erich A. Nigg1
Abstract
Genome stability in animal cells requires strict control over the numbers of the organelles called centrosomes. An attractive 'licensing' model now explains how centrosome duplication is restricted to just once per cell cycle.
The centrosome is one of the most intriguing organelles found in animal cells. It organizes the construction and maintenance of the micro-tubule cytoskeleton, a molecular 'scaffold' that confers shape and polarity on the cell1.
- Erich A. Nigg is at the Max Planck Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Email: nigg@biochem.mpg.de
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