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Nature 442, 818-822 (16 July 2006) | doi:10.1038/nature04980;
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
Leukaemias and other cancers possess a rare population of cells capable of the limitless self-renewal necessary for cancer initiation and maintenance. Eradication of these cancer stem cells is probably a critical part of any successful anti-cancer therapy, and may explain why conventional cancer therapies are often effective in reducing tumour burden, but are only rarely curative.
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