Table of contents
Volume 442 Number 7104 pp719-846
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Editorials
Round objects p719
Planets are spherical, and the International Astronomical Union's attempt to make this part of their definition has merit.
doi:10.1038/442719a
Revival in Iran p719
Whatever its motivation, Iran's support for education and science is to be welcomed.
doi:10.1038/442719b
Preventing cancer p720
More support is required to tackle obesity as a means of cancer prevention.
doi:10.1038/442720a
News
Planets are round. Will that do? p724
Astronomers attempt to break deadlock over definition.
Jenny Hogan
doi:10.1038/442724a
AIDS meeting urged to rethink prevention strategy p724
Researchers seek new ways to fight disease.
Erika Check
doi:10.1038/442724b
Homing in on the genes for humanity p725
What makes us different from chimps?
Kerri Smith
doi:10.1038/442725a
Sidelines p726
doi:10.1038/442726a
Guilty, but no jail sentence for Russian scientist p726
Human-rights groups condemn conviction.
Quirin Schiermeier
doi:10.1038/442726b
The outlook for Amazonia is dry p726
Drought of 2005 is a taste of things to come.
Jim Giles
doi:10.1038/442726c
Florida lures research institutes east p729
Sunshine state appeals to Californian expertise.
Rex Dalton
doi:10.1038/442729a
The methane mystery p730
The claim that living plants emit the greenhouse gas methane has shaken up atmospheric scientists. Quirin Schiermeier talks to the experts trying to make sense of the measurements.
doi:10.1038/442730a
News in brief p732
doi:10.1038/442732a
Correction p732
doi:10.1038/442732b
Business
More fizz at Pfizer? p734
Young blood is taking the helm at the world's biggest drug firm. Colin Macilwain assesses whether this is likely to revive its share price.
doi:10.1038/442734a
News Features
Cancer: New fronts in an old war p735
doi:10.1038/442735a
See also: Editor's summary
Cancer: Caught in time p736
The detection of cancer at an early stage in its development can be life-saving. With research efforts under way to find better methods to detect minuscule tumours, Laura Spinney finds out how near some of these cancer 'biomarkers' are to the clinic.
doi:10.1038/442736a
Cancer: Off by a whisker p739
Much of what we know about cancer comes from studying mice, and potential therapies are tested in the animals. But the differences between the species can scupper the best laid plans of researchers and drug companies, reports Carina Dennis.
doi:10.1038/442739a
Cancer: The root of the problem p742
Is targeting cancer stem cells a way to finish tumours off once and for all — or just the latest in a long line of false dawns? Alison Abbott looks at a debate that's generating both heat and light.
doi:10.1038/442742a
Correspondence
Conservation requires multiple approaches p744
Kamaljit S. Bawa
doi:10.1038/442744a
Researchers should ensure that their actions are lawful p744
Peter Cohen
doi:10.1038/442744b
Wiki and other ways to share learning online p744
Stephen Caddick
doi:10.1038/442744c
It's easier to patent plants than to publish research p744
U. C. Lavania
doi:10.1038/442744d
Books and Arts
Defining moments p745
What are the major principles that controlled the origin of life?
David Penny reviews Singularities: Landmarks on the Pathways of Life by Christian de Duve
doi:10.1038/442745a
Secret giants p746
Jon Agar reviews Colossus: The Secrets of Bletchley Park's Codebreaking Computers edited by B. Jack Copeland
doi:10.1038/442746a
Exhibition: Discovering the invisible p747
doi:10.1038/442747a
Small science, big challenge p747
Julia A. Moore reviews Nanotechnology: New Promises, New Dangers by Toby Shelley
doi:10.1038/442747b
News and Views
Quantum physics: A spin solo p749
Quantum computers could solve problems insurmountable to conventional computers. The missing ingredient for quantum computing with electron spins is now available — the rotation of a single spin.
Guido Burkard
doi:10.1038/442749a
See also: Editor's summary
Genomics: Predictable packaging p750
Nuclear factors must access specific sites within genomic DNA to function, yet the DNA is bundled up into many nucleosomes. Is the DNA sequence sufficiently informative to predict where each nucleosome will be?
Timothy J. Richmond
doi:10.1038/442750a
See also: Editor's summary
50 & 100 years ago p751
doi:10.1038/442751a
Solid-state physics: Resistance is futile p752
With the right combination of microwave radiation and magnetic field, two-dimensional electron systems conduct electricity with zero resistance. But is this zero really zero, or is it negative resistance in disguise?
Adam C. Durst
doi:10.1038/442752a
Astronomy: Young spirals get older p753
These days, galaxies come in very different shapes and sizes. Cutting-edge technologies allow a detailed peek at how things looked in the Universe's early days — 'the same, but different' is the tentative message.
Robert C. Kennicutt, Jr
doi:10.1038/442753a
See also: Editor's summary
Cancer biology: A game of subversion p754
Just as stem cells are crucial for tissue development and regeneration, cancer stem cells underlie tumour formation and maintenance. But do cancer stem cells invariably arise from normal stem cells?
Emmanuelle Passegué
doi:10.1038/442754a
See also: Editor's summary
Obituary: George W. Wetherill (1925–2006) p756
Geochemist, planetary scientist and astrobiologist.
Alan P. Boss
doi:10.1038/442756a
Brief Communications
Silent spread of H5N1 in vaccinated poultry p757
A chink in the protection of a caged flock can dramatically increase the chances of a flu outbreak.
Nicholas J. Savill, Suzanne G. St Rose, Matthew J. Keeling and Mark E. J. Woolhouse
doi:10.1038/442757a
First paragraph | Full Text | PDF (149K) | Supplementary information
See also: Editor's summary
Top of page
Brief Communications Arising
Cell biology: Nondisjunction, aneuploidy and tetraploidy pE9
Beth A. A. Weaver, Alain D. Silk and Don W. Cleveland
doi:10.1038/nature05139
First paragraph | Full Text | PDF (313K)
Cell biology: Nondisjunction, aneuploidy and tetraploidy (Reply) pE10
Qinghua Shi and Randall W. King
doi:10.1038/nature05140
First paragraph | Full Text | PDF (313K)
Review
Multiferroic and magnetoelectric materials p759
W. Eerenstein, N. D. Mathur and J. F. Scott
doi:10.1038/nature05023
Abstract | Full Text | PDF (354K)
See also: Editor's summary
Articles
Driven coherent oscillations of a single electron spin in a quantum dot p766
F. H. L. Koppens, C. Buizert, K. J. Tielrooij, I. T. Vink, K. C. Nowack, T. Meunier, L. P. Kouwenhoven and L. M. K. Vandersypen
doi:10.1038/nature05065
Abstract | Full Text | PDF (1,264K) | Supplementary information
See also: Editor's summary
A genomic code for nucleosome positioning p772
Eran Segal, Yvonne Fondufe-Mittendorf, Lingyi Chen, AnnChristine Thåström, Yair Field, Irene K. Moore, Ji-Ping Z. Wang and Jonathan Widom
doi:10.1038/nature04979
Abstract | Full Text | PDF (952K) | Supplementary information
See also: Editor's summary
PML inhibits HIF-1
translation and neoangiogenesis through repression of mTOR p779
Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya-Feldstein, Carlos Cordon-Cardo, M. Celeste Simon, Shahin Rafii and Pier Paolo Pandolfi
doi:10.1038/nature05029
Abstract | Full Text | PDF (792K) | Supplementary information
See also: Editor's summary
Letters
The rapid formation of a large rotating disk galaxy three billion years after the Big Bang p786
R. Genzel, L. J. Tacconi, F. Eisenhauer, N. M. Förster Schreiber, A. Cimatti, E. Daddi, N. Bouché, R. Davies, M. D. Lehnert, D. Lutz, N. Nesvadba, A. Verma, R. Abuter, K. Shapiro, A. Sternberg, A. Renzini, X. Kong, N. Arimoto and M. Mignoli
doi:10.1038/nature05052
First paragraph | Full Text | PDF (376K) | Supplementary information
See also: Editor's summary
No signature of clear CO2 ice from the 'cryptic' regions in Mars' south seasonal polar cap p790
Yves Langevin, Sylvain Douté, Mathieu Vincendon, François Poulet, Jean-Pierre Bibring, Brigitte Gondet, Bernard Schmitt and F. Forget
doi:10.1038/nature05012
First paragraph | Full Text | PDF (322K) | Supplementary information
See also: Editor's summary
CO2 jets formed by sublimation beneath translucent slab ice in Mars' seasonal south polar ice cap p793
Hugh H. Kieffer, Philip R. Christensen and Timothy N. Titus
doi:10.1038/nature04945
First paragraph | Full Text | PDF (648K)
See also: Editor's summary
Spontaneous skyrmion ground states in magnetic metals p797
U. K. Rö
ler,
A. N. Bogdanov
and
C. Pfleiderer
doi:10.1038/nature05056
First paragraph | Full Text | PDF (842K) | Supplementary information
See also: Editor's summary
Resonant slow fault slip in subduction zones forced by climatic load stress p802
Anthony R. Lowry
doi:10.1038/nature05055
First paragraph | Full Text | PDF (1,358K) | Supplementary information
Archaea predominate among ammonia-oxidizing prokaryotes in soils p806
S. Leininger, T. Urich, M. Schloter, L. Schwark, J. Qi, G. W. Nicol, J. I. Prosser, S. C. Schuster and C. Schleper
doi:10.1038/nature04983
First paragraph | Full Text | PDF (298K) | Supplementary information
See also: Editor's summary
Hierarchy and adaptivity in segmenting visual scenes p810
Eitan Sharon, Meirav Galun, Dahlia Sharon, Ronen Basri and Achi Brandt
doi:10.1038/nature04977
First paragraph | Full Text | PDF (411K) | Supplementary information
See also: Editor's summary
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology p814
Yong Kim, Jee Young Sung, Ilaria Ceglia, Ko-Woon Lee, Jung-Hyuck Ahn, Jonathan M. Halford, Amie M. Kim, Seung P. Kwak, Jong Bae Park, Sung Ho Ryu, Annette Schenck, Barbara Bardoni, John D. Scott, Angus C. Nairn and Paul Greengard
doi:10.1038/nature04976
First paragraph | Full Text | PDF (556K) | Supplementary information
Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 p818
Andrei V. Krivtsov, David Twomey, Zhaohui Feng, Matthew C. Stubbs, Yingzi Wang, Joerg Faber, Jason E. Levine, Jing Wang, William C. Hahn, D. Gary Gilliland, Todd R. Golub and Scott A. Armstrong
doi:10.1038/nature04980
First paragraph | Full Text | PDF (637K) | Supplementary information
See also: Editor's summary | News and Views by Passegué
Notch signalling regulates stem cell numbers in vitro and in vivo p823
Andreas Androutsellis-Theotokis, Ronen R. Leker, Frank Soldner, Daniel J. Hoeppner, Rea Ravin, Steve W. Poser, Maria A. Rueger, Soo-Kyung Bae, Raja Kittappa and Ronald D. G. McKay
doi:10.1038/nature04940
First paragraph | Full Text | PDF (392K) | Supplementary information
See also: Editor's summary
Protein flexibility acclimatizes photosynthetic energy conversion to the ambient temperature p827
Oksana Shlyk-Kerner, Ilan Samish, David Kaftan, Neta Holland, P. S. Maruthi Sai, Hadar Kless and Avigdor Scherz
doi:10.1038/nature04947
First paragraph | Full Text | PDF (368K) | Supplementary information
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease p831
Ivo C. Lorenz, Joseph Marcotrigiano, Thomas G. Dentzer and Charles M. Rice
doi:10.1038/nature04975
First paragraph | Full Text | PDF (617K) | Supplementary information
See also: Editor's summary
DNA overwinds when stretched p836
Jeff Gore, Zev Bryant, Marcelo Nöllmann, Mai U. Le, Nicholas R. Cozzarelli and Carlos Bustamante
doi:10.1038/nature04974
First paragraph | Full Text | PDF (951K) | Supplementary information
Corrigendum: Structure of the Sec13/31 COPII coat cage p840
Scott M. Stagg, Cemal Gürkan, Douglas M. Fowler, Paul LaPointe, Ted R. Foss, Clinton S. Potter, Bridget Carragher and William E. Balch
doi:10.1038/nature05141
Naturejobs
ProspectProspects p841
UK graduate students and postdocs are not getting stipend top-ups, despite available funds.
Paul Smaglik
doi:10.1038/nj7104-841a
Postdocs and Students
Winning ways p842
Science is cut-throat by nature, but how should young scientists handle working on competitive projects — or worse, getting scooped? Kendall Powell investigates how to release the pressure valve.
Kendall Powell
doi:10.1038/nj7104-842a
Highlights
Highlight: The National Institutes of Health
doi:10.1038/nj0123
