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Brief Communications Arising
Nature 442, E9-E10 (17 August 2006) | doi:10.1038/nature05139; Published online 16 August 2006
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Cell biology: Nondisjunction, aneuploidy and tetraploidy
Beth A. A. Weaver1, Alain D. Silk1 & Don W. Cleveland1
Abstract
Arising from: Q. Shi & R. W. King Nature 437, 1038–1042 (2005); Shi & King reply
One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction — a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King1 challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.
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RESEARCH
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell linesNature Letters to Editor (13 Oct 2005)
Cell biology Nondisjunction, aneuploidy and tetraploidy (Reply)Nature Brief Communication (17 Aug 2006)
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