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News and Views
Nature 442, 750-752 (17 August 2006) | doi:10.1038/442750a; Published online 16 August 2006
Genomics: Predictable packaging
Timothy J. Richmond1
Abstract
Nuclear factors must access specific sites within genomic DNA to function, yet the DNA is bundled up into many nucleosomes. Is the DNA sequence sufficiently informative to predict where each nucleosome will be?
The genomes of eukaryotic organisms — plants, fungi and animals — range in length from 10 million to 100 billion base pairs. All of this DNA is packaged into a structure known as chromatin so that it can fit into the cell nucleus, which is only a few micrometres in diameter.
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