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From the following article:

PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR

Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya-Feldstein, Carlos Cordon-Cardo, M. Celeste Simon, Shahin Rafii and Pier Paolo Pandolfi

Nature 442, 779-785(17 August 2006)

doi:10.1038/nature05029

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Pml-/- mice have accelerated revascularization in response to ischaemia.

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Figure 2

Pml controls Hif-1alpha activity and accumulation rate in hypoxic conditions.

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Figure 3

PML regulates mTOR in response to hypoxia.

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Figure 4

PML inhibits mTOR activity through physical interaction and co-localization in the nucleus.

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Figure 5

Pml-/- tumours have increased angiogenesis, phosphorylation of S6 and sensitivity to rapamycin.

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