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From the following article:

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

Andrei V. Krivtsov, David Twomey, Zhaohui Feng, Matthew C. Stubbs, Yingzi Wang, Joerg Faber, Jason E. Levine, Jing Wang, William C. Hahn, D. Gary Gilliland, Todd R. Golub and Scott A. Armstrong

Nature 442, 818-822(17 August 2006)

doi:10.1038/nature04980

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Leukaemic-GMP are enriched for leukaemia stem cells.

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Figure 2

Progenitor-derived leukaemia stem cells maintain progenitor identity and re-activate a self-renewal-associated programme.

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Figure 3

The self-renewal-associated signature is found in human MLL-rearranged AML and activated as a hierarchy of gene expression.

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Figure 4

Hox genes and Mef2c play a role in L-GMP.

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