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Nature 442, 684-687 (10 August 2006) | doi:10.1038/nature04863;
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Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements
Bilaterian animals have a Hox gene cluster essential for patterning the main body axis, and a ParaHox gene cluster. Comparison of Hox and ParaHox genes has led workers to postulate that both clusters originated from the duplication of an ancient cluster named ProtoHox, which contained up to four genes with at least the precursors of anterior and posterior Hox/ParaHox genes.
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