FIGURE 3. Functional analysis of CaM-dependent pathway in beak development.
From the following article:
The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches
Arhat Abzhanov, Winston P. Kuo, Christine Hartmann, B. Rosemary Grant, Peter R. Grant and Clifford J. Tabin
Nature 442, 563-567(3 August 2006)
doi:10.1038/nature04843
a, b, Whole head views of embryonic day 10 (E10; HH stage 36) wild-type (a) and RCAS::CA-CaMKII-infected (b) chicken embryos. The length of the beak is shown with a red line; the depth of the beak at the base and the depth of the beak at the tip are shown with blue and green lines, respectively. c–j, We used RSCH (c, d), Coll IX (e, f), Runx2 (g, h) and PTHrP-Rec (i, j) probes to reveal RCAS infection (RSCH), chondrocytes (Coll IX) and early osteoblasts (Runx2). c, e, g, i, Wild type; d, f, h, j, RCAS::CA-CaMKII infected. The star indicates an egg-tooth. Scale bar, 2 mm in a.
