Editorials

Come veto or high water p329

The obduracy of the White House will slow the progress of stem-cell research in the United States — just as Europe agrees to move forward with it.

doi:10.1038/442329a

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Still not alert p330

Tsunami preparations in the Indian Ocean remain inadequate.

doi:10.1038/442330a

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Let's replicate p330

Post-publication follow-up evolves.

doi:10.1038/442330b

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Research Highlights

Research highlights p332

doi:10.1038/442332a

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News

Nigeria ready for huge science spend p334

Oil revenues set to establish national research foundation.

Jim Giles

doi:10.1038/442334a

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A long week in stem-cell politics... p335

Europe and the United States still divided over embryo cells.

Meredith Wadman and Alison Abbott

doi:10.1038/442335a

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The lure of stem-cell lines p336

Nature investigates what human embryonic stem-cell lines have been derived worldwide so far, and why scientists are so desperate to work with new ones.

doi:10.1038/442336a

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Wildlife caught in crossfire of US immigration battle p338

Crackdown on illegal border crossings puts endangered species at further risk.

Emma Marris

doi:10.1038/442338a

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Sidelines p339

doi:10.1038/442339a

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Carbon credits for the Joneses p340

UK politician advocates domestic emissions allowance.

Jim Giles

doi:10.1038/442340a

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News in brief p341

doi:10.1038/442341a

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Correction p341

doi:10.1038/442341b

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Business

Break with tradition p342

Traditional medicine has spent decades in the wings of pharmacology. Now India is pushing it to centre stage, as K. S. Jayaraman reports.

doi:10.1038/442342a

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In brief p343

doi:10.1038/442343a

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Market watch p343

doi:10.1038/442343b

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News Features

The trouble with replication p344

The idea that readers should be able to replicate published scientific results is seen as the bedrock of modern science. But what if replication proves difficult or impossible? Jim Giles tracks the fate of one group of papers.

doi:10.1038/442344a

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See also: Editor's summary

Bird flu: On border patrol p348

The United States has embarked on a huge effort to try to track the H5N1 avian flu virus in birds migrating into the country. But is surveillance more urgently needed elsewhere? Erika Check reports.

doi:10.1038/442348a

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Lab on a chip: A little goes a long way p351

Faster, safer and easier to control — chemical reactions in microreactors are taking off in the lab. Now industry is being seduced by the charms of the lab on a chip. Jenny Hogan investigates.

doi:10.1038/442351a

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Correspondence

Hungary: academy is not obsolete or discriminatory p353

György Fábri

doi:10.1038/442353a

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Hungary: academy needs more than internal reform p353

Csaba Szabo

doi:10.1038/442353b

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Quest for seed immortality is mission impossible p353

Andreas Graner and Andreas Börner

doi:10.1038/442353c

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No place for secrets in scientific research p353

Clifford B. Saper

doi:10.1038/442353d

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Books and Arts

Design flaws p355

Destroying the argument that intelligent design has a scientific basis.

John Tyler Bonner reviews Intelligent Thought: Science Versus the Intelligent Design Movement edited by John Brockman

doi:10.1038/442355a

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See also: Editor's summary

Diary of a weed p356

Anthony Trewavas reviews Seed to Seed: The Secret Life of Plants by Nicholas Harberd

doi:10.1038/442356a

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The body bared p356

doi:10.1038/442356b

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Playing the numbers game p357

David Colquhoun reviews Does Measurement Measure Up? How Numbers Reveal and Conceal the Truth by John M. Henshaw

doi:10.1038/442357a

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News and Views

Semiconductor physics: Magnetic manipulations p359

A deft technique allows magnetic atoms to be placed one by one in a semiconductor crystal. It's a further step towards an ambitious goal: a computer chip that might simultaneously store and manipulate data.

Nitin Samarth

doi:10.1038/442359a

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See also: Editor's summary

Protein folding: Inside the cage p360

Many newly synthesized bacterial proteins avoid aggregation by folding inside a chaperonin nanocage. Unexpectedly, it turns out that the cage's internal properties can be optimized to accelerate folding.

R. John Ellis

doi:10.1038/442360a

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50 & 100 years ago p361

doi:10.1038/442361a

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Planetary science: Titan's exotic weather p362

Titan is viewed as a sibling of Earth, as both bodies have rainy weather systems and landscapes formed by rivers. But as we study these similarities, Titan emerges as an intriguingly foreign world.

Caitlin A. Griffith

doi:10.1038/442362a

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See also: Editor's summary

Developmental biology: The hole picture p363

What's the best way to make a tube? Roll up a sheet? Hollow out a solid rod? Some innovative movies show how the problem is tackled during the development of blood vessels in embryos.

Keith Mostov and Fernando Martin-Belmonte

doi:10.1038/442363a

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Astronomy: Revealing flares p364

Transient bursts of cosmic light provide a unique window on what's going on in the distant Universe. But similar bursts closer to home may be muddying the view, and hopes rest on a new tool to resolve things.

J. Anthony Tyson

doi:10.1038/442364a

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Developmental neurobiology: A destructive switch for neurons p365

In the developing nervous system, tremendous multiplication and diversification of cells elaborate the exquisite pattern of the brain. But how do cells shift from early proliferation to assume their mature states?

Peter K. Jackson

doi:10.1038/442365a

Full Text | PDF (407K)

Article

Snapshots of tRNA sulphuration via an adenylated intermediate p419

Tomoyuki Numata, Yoshiho Ikeuchi, Shuya Fukai, Tsutomu Suzuki and Osamu Nureki

doi:10.1038/nature04896

Abstract | Full Text | PDF (848K) | Supplementary information

See also: Editor's summary

Letters

A low fraction of nitrogen in molecular form in a dark cloud p425

S. Maret, E. A. Bergin and C. J. Lada

doi:10.1038/nature04919

First paragraph | Full Text | PDF (222K) | Supplementary information

See also: Editor's summary

Methane storms on Saturn's moon Titan p428

R. Hueso and A. Sánchez-Lavega

doi:10.1038/nature04933

First paragraph | Full Text | PDF (258K) | Supplementary information

See also: Editor's summary | News and Views by Griffith

Methane drizzle on Titan p432

Tetsuya Tokano, Christopher P. McKay, Fritz M. Neubauer, Sushil K. Atreya, Francesca Ferri, Marcello Fulchignoni and Hasso B. Niemann

doi:10.1038/nature04948

First paragraph | Full Text | PDF (177K) | Supplementary information

See also: Editor's summary | News and Views by Griffith

Atom-by-atom substitution of Mn in GaAs and visualization of their hole-mediated interactions p436

Dale Kitchen, Anthony Richardella, Jian-Ming Tang, Michael E. Flatté and Ali Yazdani

doi:10.1038/nature04971

First paragraph | Full Text | PDF (358K) | Supplementary information

See also: Editor's summary | News and Views by Samarth

Widespread active detachment faulting and core complex formation near 13° N on the Mid-Atlantic Ridge p440

Deborah K. Smith, Johnson R. Cann and Javier Escartín

doi:10.1038/nature04950

First paragraph | Full Text | PDF (607K)

A ubiquitous thermoacidophilic archaeon from deep-sea hydrothermal vents p444

Anna-Louise Reysenbach, Yitai Liu, Amy B. Banta, Terry J. Beveridge, Julie D. Kirshtein, Stefan Schouten, Margaret K. Tivey, Karen L. Von Damm and Mary A. Voytek

doi:10.1038/nature04921

First paragraph | Full Text | PDF (431K) | Supplementary information

See also: Editor's summary

Strategies for mitigating an influenza pandemic p448

Neil M. Ferguson, Derek A. T. Cummings, Christophe Fraser, James C. Cajka, Philip C. Cooley and Donald S. Burke

doi:10.1038/nature04795

First paragraph | Full Text | PDF (385K) | Supplementary information

See also: Editor's summary

Endothelial tubes assemble from intracellular vacuoles in vivo p453

Makoto Kamei, W. Brian Saunders, Kayla J. Bayless, Louis Dye, George E. Davis and Brant M. Weinstein

doi:10.1038/nature04923

First paragraph | Full Text | PDF (381K) | Supplementary information

See also: Editor's summary | News and Views by Mostov & Martin-Belmonte

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase- and PTEN p457

Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V. Forrester, Henry R. Bourne, Peter N. Devreotes, Colin D. McCaig and Josef M. Penninger

doi:10.1038/nature04925

First paragraph | Full Text | PDF (801K) | Supplementary information

See also: Editor's summary

IL-23 promotes tumour incidence and growth p461

John L. Langowski, Xueqing Zhang, Lingling Wu, Jeanine D. Mattson, Taiying Chen, Kathy Smith, Beth Basham, Terrill McClanahan, Robert A. Kastelein and Martin Oft

doi:10.1038/nature04808

First paragraph | Full Text | PDF (492K) | Supplementary information

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ATM stabilizes DNA double-strand-break complexes during V(D)J recombination p466

Andrea L. Bredemeyer, Girdhar G. Sharma, Ching-Yu Huang, Beth A. Helmink, Laura M. Walker, Katrina C. Khor, Beth Nuskey, Kathleen E. Sullivan, Tej K. Pandita, Craig H. Bassing and Barry P. Sleckman

doi:10.1038/nature04866

First paragraph | Full Text | PDF (483K) | Supplementary information

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth p471

Anna Lasorella, Judith Stegmüller, Daniele Guardavaccaro, Guangchao Liu, Maria S. Carro, Gerson Rothschild, Luis de la Torre-Ubieta, Michele Pagano, Azad Bonni and Antonio Iavarone

doi:10.1038/nature04895

First paragraph | Full Text | PDF (561K) | Supplementary information

See also: News and Views by Jackson

Molecular architecture of axonemal microtubule doublets revealed by cryo-electron tomography p475

Haixin Sui and Kenneth H. Downing

doi:10.1038/nature04816

First paragraph | Full Text | PDF (393K) | Supplementary information

Naturejobs

Prospects p479

Looking for the best way to balance lab life and family.

Paul Smaglik

doi:10.1038/nj7101-479a

Full Text | PDF (167K)

Trial blazers p480

The drug industry may be going through lean times, as new candidates have to clear ever-higher safety hurdles. But this gives scientists who can steer a drug through clinical trials a head start in the job market, says Hannah Hoag.

Hannah Hoag

doi:10.1038/nj7101-480a

Full Text | PDF (605K)

Matthias Kleiner, president, DFG, Bonn, Germany p482

Matthias Kleiner is first engineer to head Germany's DFG.

Friederike Siegel

doi:10.1038/nj7101-482a

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Where are the physician-scientists? p482

Physician-scientists wanted.

Alfredo Quiñones-Hinojosa

doi:10.1038/nj7101-482b

Full Text | PDF (94K)

Lab makeover p482

Giving the lab a new look.

Milan de Vries

doi:10.1038/nj7101-482c

Full Text | PDF (94K)

Futures

Golden year p484

The gift of memories.

Igor Teper

doi:10.1038/442484a

Full Text | PDF (162K)