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Volume 442 Issue 7101, 27 July 2006

Editorial

  • The obduracy of the White House will slow the progress of stem-cell research in the United States — just as Europe agrees to move forward with it.

    Editorial

    Advertisement

  • Tsunami preparations in the Indian Ocean remain inadequate.

    Editorial
  • Post-publication follow-up evolves.

    Editorial
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Research Highlights

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News

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News in Brief

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Correction

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Business

  • Traditional medicine has spent decades in the wings of pharmacology. Now India is pushing it to centre stage, as K. S. Jayaraman reports.

    Business
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News Feature

  • The idea that readers should be able to replicate published scientific results is seen as the bedrock of modern science. But what if replication proves difficult or impossible? Jim Giles tracks the fate of one group of papers.

    • Jim Giles
    News Feature
  • The United States has embarked on a huge effort to try to track the H5N1 avian flu virus in birds migrating into the country. But is surveillance more urgently needed elsewhere? Erika Check reports.

    • Erika Check
    News Feature
  • Faster, safer and easier to control — chemical reactions in microreactors are taking off in the lab. Now industry is being seduced by the charms of the lab on a chip. Jenny Hogan investigates.

    • Jenny Hogan
    News Feature
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Correspondence

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Books & Arts

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News & Views

  • A deft technique allows magnetic atoms to be placed one by one in a semiconductor crystal. It's a further step towards an ambitious goal: a computer chip that might simultaneously store and manipulate data.

    • Nitin Samarth
    News & Views
  • Many newly synthesized bacterial proteins avoid aggregation by folding inside a chaperonin nanocage. Unexpectedly, it turns out that the cage's internal properties can be optimized to accelerate folding.

    • R. John Ellis
    News & Views
  • Titan is viewed as a sibling of Earth, as both bodies have rainy weather systems and landscapes formed by rivers. But as we study these similarities, Titan emerges as an intriguingly foreign world.

    • Caitlin A. Griffith
    News & Views
  • What's the best way to make a tube? Roll up a sheet? Hollow out a solid rod? Some innovative movies show how the problem is tackled during the development of blood vessels in embryos.

    • Keith Mostov
    • Fernando Martin-Belmonte
    News & Views
  • Transient bursts of cosmic light provide a unique window on what's going on in the distant Universe. But similar bursts closer to home may be muddying the view, and hopes rest on a new tool to resolve things.

    • J. Anthony Tyson
    News & Views
  • In the developing nervous system, tremendous multiplication and diversification of cells elaborate the exquisite pattern of the brain. But how do cells shift from early proliferation to assume their mature states?

    • Peter K. Jackson
    News & Views
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Introduction

    • Rosamund Daw
    • Joshua Finkelstein
    Introduction
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Overview

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Review Article

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Article

  • Molecular 'snapshots' of the MnmA thiouridylase–tRNA complex reveal that during RNA sulphuration, a key α-helix forms around the active site, burying U34 into the catalytic pocket. This 'closed' conformation of the active site ensures that sulphur is incorporated into uridine at the correct place.

    • Tomoyuki Numata
    • Yoshiho Ikeuchi
    • Osamu Nureki
    Article
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Letter

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Prospects

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Special Report

  • The drug industry may be going through lean times, as new candidates have to clear ever-higher safety hurdles. But this gives scientists who can steer a drug through clinical trials a head start in the job market, says Hannah Hoag.

    • Hannah Hoag
    Special Report
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Movers

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Recruiters and Academia

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Graduate Journal

  • Giving the lab a new look.

    • Milan de Vries
    Graduate Journal
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Futures

  • The gift of memories.

    • Igor Teper
    Futures
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Authors

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Insight

  • The ability to perform experiments on small scales using miniaturized (lab-on-a-chip) devices has many benefits, and highly integrated and compact labs on chips with exciting functionality have been developed despite the engineering challenges involved. This Insight highlights recent advances in the application of microfluidic-chip-based technologies such as chemical synthesis, the study of cellular metabolism and medical diagnostics.

    Insight
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