Supplementary information
From the following article:
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
Xiaojing Pan, Sudharshan Eathiraj, Mary Munson and David G. Lambright
Nature 442, 303-306(20 July 2006)
doi:10.1038/nature04847
Supplementary Figure S1
Identification of Rab GTPase substrates for the Gyp1p TBC domain.
Supplementary Figure S2
Gyp1p and Rab33 form a complex in the presence of aluminum fluoride.
Supplementary Figure S3
Additional information relevant to structure determination.
Supplementary Figure S4
Conservation and variability within the interface between Gyp1p and Rab33.
Supplementary Figure S5
Comparison of the structures of Gyp1p and Rab33 alone and in the complex.
Supplementary Figure S6
Kinetics of GTP hydrolysis catalyzed by the Gyp1p and Gyp7p TBC domains.
Supplementary Figure S7
Western blot analysis of wild type and mutant Gyp1p expression.
Supplementary Table S2
Data collection, phasing, and refinement statistics.
Supplementary Methods
This file contains supplementary methods, including one table and eight references.
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