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Nature 442, 255-256 (20 July 2006) | doi:10.1038/442255a; Published online 19 July 2006

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Structural biology: Proteins downhill all the way

Jeffery W. Kelly1

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The hundreds of hydrogen atoms in a protein can be used as reporters to describe how the protein folds into and out of shape. The results challenge the dogma that this is always an all-or-nothing process.

The three-dimensional structures of proteins govern their activity, yet we know far less than we would like to about how these molecules fold into shape. Proteins use an intricate network of weak, non-covalent interactions to acquire the folded state1.

  1. Jeffery W. Kelly is in the Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
    Email: jkelly@scripps.edu

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