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Nature 442, 203-207 (4 June 2006) | doi:10.1038/nature04916;
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Professor of Microscopy (W2)
- Friedrich-Schiller-University
- Jena Germany
Senior Faculty Positions
- Torrey Pines Institute for Molecular Studies
- Port St. Lucie, FL
A novel class of small RNAs bind to MILI protein in mouse testes
Small RNAs bound to Argonaute proteins recognize partially or fully complementary nucleic acid targets in diverse gene-silencing processes. A subgroup of the Argonaute proteins—known as the ‘Piwi family’—is required for germ- and stem-cell development in invertebrates, and two Piwi members—MILI and MIWI—are essential for spermatogenesis in mouse.
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