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Nature 442, 33-34 (6 July 2006) | doi:10.1038/442033a; Published online 5 July 2006

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Virology: Micro mystery solution

Bill Sugden1

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A particular talent of herpes simplex virus-1 is that it can lurk unseen in the cells of an infected person for long periods. It turns out that the virus achieves this feat through the agency of a microRNA.

Herpes simplex virus-1 (HSV-1) infects most of us but then stays hidden for most of our lives. When it does re-emerge, the virus usually causes cold sores; its close cousin, HSV-2, can likewise hide, then re-emerge to cause distressing and painful genital sores.

  1. Bill Sugden is in the McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA.
    Email: sugden@oncology.wisc.edu

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