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Nature 441, 1157-1161 (3 May 2006) | doi:10.1038/nature04788;
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Manager Medical Writitng
- Indegene Lifesystems Pvt. Ltd
- Bengaluru 560 071 India
Assistant Professor
- University of Michigan
- Michigan, MI 48109 United States
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's disease characterized by motor disturbances and dopaminergic neurodegeneration. To address its underlying molecular pathogenesis, we generated and characterized loss-of-function mutants of Drosophila PTEN-induced putative kinase 1 (PINK1 ), a novel AR-JP-linked gene.
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Abstract
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