Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 441, 1080-1086 (29 June 2006) | doi:10.1038/nature04958; Published online 28 June 2006
Open Innovation Challenges
- More Challenges
- Powered by:
nature jobs
Postdoctoral Positions
- Johns Hopkins University
- Baltimore, Maryland, USA
Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation
- Syngene International
- Bangalore, Karnataka 560099 India
Review article Stem cells, ageing and the quest for immortality
Thomas A. Rando1
Abstract
Listen to an interview with Tom Rando on the stem cells podcast
Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Ageing From stem to sternNature News and Views (20 Sep 2007)
Serum of youth?Nature Biotechnology News and Views (01 Apr 2005)
Stressed marrow: FoxOs stem tumour growthNature Cell Biology News and Views (01 Mar 2007)
The adult muscle stem cell comes of ageNature Medicine News and Views (01 Aug 2005)
Reproductive cloning conserves cellular senescenceNature Cell Biology News and Views (01 Jun 2003)
