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Nature 441, 1080-1086 (29 June 2006) | doi:10.1038/nature04958; Published online 28 June 2006
nature jobs
Postdoctoral position in Neuroscience
- Bioengineering Institute (University Miguel Hernández) and CIBER-BBN (Networking Research Center on Bioengineering, Biomaterials and Nanomedicine)
- Elche, SPAIN
Research Fellows in Pluripotent Stem Cell Technology
- The University of Nottingham
- Nottingham, UK
Review article Stem cells, ageing and the quest for immortality
Thomas A. Rando1
Abstract
Listen to an interview with Tom Rando on the stem cells podcast
Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
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