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Nature 441, 1075-1079 (29 June 2006) | doi:10.1038/nature04957; Published online 28 June 2006
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Sr. Scientific Manager / Chief Scientific Manager- Discovery Metabolism and Pharmacokinetics (MAP)
- Syngene International
- Bangalore, Karnataka 560099 India
30 Doctoral Stipends for Outstanding Young Researchers
- Christian-Albrechts-Universitat zu Kiel
- Kiel, Germany
Review article The stem-cell niche as an entity of action
David T. Scadden1
Abstract
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Stem-cell populations are established in 'niches' — specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.
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