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Nature 441, 1087-1093 (29 June 2006) | doi:10.1038/nature04959; Published online 28 June 2006
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Head of Formulation R&D
- Syngene International Limited
- Bangalore 560 099 India
Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Review article Generation of neuronal variability and complexity
Alysson R. Muotri1 & Fred H. Gage1
Abstract
Listen to an interview with Fred Gage on the stem cells podcast
The production of specialized differentiated neurons derived from stem cells has been proposed as a revolutionary technology for regenerative medicine. However, few examples of specific neuronal cell differentiation have been described so far. Although stem-cell tissue replacement might be seemingly straightforward in other cases, the high degree of complexity of the nervous system raises the challenge of tissue replacement substantially. Understanding mechanisms of neuronal diversification will not only be relevant for therapeutic purposes but might also shed light on the differences in cognitive abilities, personality traits and psychiatric conditions observed in humans.
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