Access
To read this story in full you will need to login or make a payment (see right).
Insight
Nature 441, 1068-1074 (29 June 2006) | doi:10.1038/nature04956; Published online 28 June 2006
Review article Asymmetric and symmetric stem-cell divisions in development and cancer
Sean J. Morrison1 & Judith Kimble2
Abstract
Listen to an interview with Sean Morrison on the stem cells podcast
Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Stem cells To be and not to beNature News and Views (25 Sep 2003)
Daughter leaves motherNature Cell Biology News and Views (01 Mar 2007)
See all 11 matches for News And Views