FIGURE 4. Potential niche contribution to dysplastic cell growth.
From the following article:
The stem-cell niche as an entity of action
David T. Scadden
Nature 441, 1075-1079(29 June 2006)
doi:10.1038/nature04957
a, Normal interactions and occupancy of the niche tightly controls stem-cell number. b, Vacancy in the niche might result in ectopic occupancy by another cell type. c, Niche signals might impose proliferative or de-differentiative signals, contributing to a disordered state of tissue organization and control.