FIGURE 3. Inputs feeding back on stem-cell function in the niche.

From the following article:

The stem-cell niche as an entity of action

David T. Scadden

Nature 441, 1075-1079(29 June 2006)

doi:10.1038/nature04957

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Elements of the local environment that participate in regulating the system of a stem cell in its tissue state are depicted. These include the constraints of the architectural space, physical engagement of the cell membrane with tethering molecules on neighbouring cells or surfaces, signalling interactions at the interface of stem cells and niche or descendent cells, paracrine and endocrine signals from local or distant sources, neural input and metabolic products of tissue activity.

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