Supplementary information
From the following article:
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Byung-Gyu Kim, Cuiling Li, Wenhui Qiao, Mizuko Mamura, Barbara Kasperczak, Miriam Anver, Lawrence Wolfraim, Suntaek Hong, Elizabeth Mushinski, Michael Potter, Seong-Jin Kim, Xin-Yuan Fu, Chuxia Deng and John J. Letterio
Nature 441, 1015-1019(22 June 2006)
doi:10.1038/nature04846
Supplementary Notes
This file contains Supplementary Methods and Supplementary Figure Legends.
Supplementary Figure 1
Smad4-dependent signaling is in stroma cells is key to maintaining intestinal homeostasis.
Supplementary Figures 2 and 3
Supplementary Figure 2 details diffuse plasma cell infiltration of intestines in mice with T cell-restricted deletion of the SMAD4 gene. Supplementary Figure 3 details epithelial-specific expression of a dominant-negative acting Smad4 transgene is not associated with spontaneous tumorigenesis.
Supplementary Figure 4
SMAD4+/co;Lck-cre mice develop plasma cell and epithelial cell hyperplasia.
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