Supplementary information
From the following article:
Distribution and three-dimensional structure of AIDS virus envelope spikes
Ping Zhu, Jun Liu, Julian Bess, Jr, Elena Chertova, Jeffrey D. Lifson, Henry Grisé, Gilad A. Ofek, Kenneth A. Taylor and Kenneth H. Roux
Nature 441, 847-852(15 June 2006)
doi:10.1038/nature04817
Supplementary Notes
This file contains Supplementary Methods, Supplementary Figure Legends, and Supplementary Movie Legends and additional references.
Supplementary Figure 1
Distribution of inter-spike centre-to-centre distances for mutant SIV and wtHIV-1.
Supplementary Figure 2
Distribution of Env spike cluster sizes on 40 HIV-1 virions compared with the distribution of clusters on hypothetical model virions with randomly placed Env spikes calculated, as described for Supplementary Figure 1.
Supplementary Figure 3
Inherent three-fold symmetry in Env spike averaged images.
Supplementary Figure 4
Z-stack of 42 sequential density sections through the 3-fold axis of the final Env spike average.
Supplementary Figure 5
Comparison of gp120 fitted trimer models.
Supplementary Figure 6
Density distribution profile of the cryoEM trimer slice through the final Env spike average showing the minimum separation between distinguishable internal density peaks measuring 3.2 nm.
Supplementary Movie 1
CryoEM tomogram of SIV virions and corresponding isosurface model.
Supplementary Movie 3
De novo fitting of gp120 atomic model into cryoEM isosurface model.
Supplementary Movie 4
CryoEM isosurface model manually fitted with gp41 peptides and docked with MAbs.
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