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Nature 441, 702-703 (8 June 2006) | doi:10.1038/441702a; Published online 7 June 2006

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Neurobiology: Extending influence

Eve Marder1

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Rather than merely firing in a digital on–off fashion, vertebrate neurons may have an analogue aspect to their signalling too — a finding that will not surprise many who have worked on invertebrate neurons.

Much of what we know about electrical signalling in the brain comes from extracellular recordings that detect when a neuron is firing action potentials. These recordings do not, however, provide continuous monitoring of the fluctuations of membrane potential, and do not capture sub-threshold changes in membrane potential such as those caused by individual synaptic events.

  1. Eve Marder is at the Volen Center and Biology Department, Brandeis University, 415 South St, Waltham, Massachusetts 02454-9110, USA.
    Email: marder@brandeis.edu

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