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Nature 441, 451-456 (24 May 2006) | doi:10.1038/nature04873;
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Tier II Canada Research Chair in Cellular Science and Human Health
- Concordia University
- Montreal, Quebec Canada
Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Validating cancer drug targets
A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is clinically effective and acts through the target against which it was designed. Nevertheless, it is desirable to declare an early-stage drug target as |[lsquo]|validated|[rsquo]| before investing in a full-scale drug discovery programme dedicated to it. Although the outcome of validation studies can guide cancer research programmes, strictly defined universal validation criteria have not been established.
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