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Nature 441, 523-527 (7 May 2006) | doi:10.1038/nature04809;
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Executive- Commercial- Corporate Office
- Rhydburg Pharmaceuticals
- Selaqui-Dehradun India
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- University of Cincinnati and Cincinnati Children's Research Foundation
- Cincinnati, OH
Identification of a tumour suppressor network opposing nuclear Akt function
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation.
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