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Nature 441, 523-527 (7 May 2006) | doi:10.1038/nature04809;
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Identification of a tumour suppressor network opposing nuclear Akt function
The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor. In such tumours, AKT becomes enriched at cell membranes where it is activated by phosphorylation.
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