Bacteria exploit stem cells and their surroundings in order to reproduce.
doi:10.1038/7092xviia
Table of contents
日本語版 Volume 441 Number 7092 ppxvii-548
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Authors
Making the paper: Horacio Frydman pxvii
Abstractions pxvii
doi:10.1038/7092xviib
Quantified: New Zealand pxvii
doi:10.1038/7092xviic
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Editorials
Policing ourselves p383
Biologists should push forward with an effort that began in California last weekend to wrestle with the implications of synthetic biology.
doi:10.1038/441383a
Coping with complexity p383
A more detailed understanding of scientific concepts does not lead to simplicity.
doi:10.1038/441383b
Carbon omissions p384
The European Union's greenhouse-gas trading system needs reinforcement.
doi:10.1038/441384a
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News
Synthetic biologists try to calm fears p388
Mars explorers seek spot for touchdown p389
Planetary scientists debate where to land next.
Tony Reichhardt
doi:10.1038/441389a
Teenager waits 40 years for recognition p390
Fossil is finally hailed as new Asian plesiosaur.
Ichiko Fuyuno
doi:10.1038/441390a
Election fever inflames the US stem-cell debate p391
Senators tackle research policy in race for seats.
Erika Check
doi:10.1038/441391a
Named and shamed p392
As accusations of scientific misconduct in China become rife, some fear persecution reminiscent of that used in the Cultural Revolution.
David Cyranoski
doi:10.1038/441392a
Sidelines p394
doi:10.1038/441394a
Physicists plead to make final tweak to fusion experiment p394
Is there time to make the ITER reactor a little fuzzy?
Geoff Brumfiel
doi:10.1038/441394b
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News Features
Genetics: What is a gene? p398
The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no clear beginning or end and RNA is a key part of the information package, reports Helen Pearson.
Helen Pearson
doi:10.1038/441398a
The dark side of the Sun p402
The Sun occasionally hurls streams of particles towards Earth, where they can wreak havoc with satellites. Predicting these solar storms is hard, but some physicists believe we're about to face the biggest bout of solar flares in years. Stuart Clark reports.
Stuart Clark
doi:10.1038/441402a
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Business
Carbon market survives gas leaks p405
Searing volatility has led some to dismiss Europe's nascent emissions market as a farce — but it is still hanging in there. Quirin Schiermeier reports on the project's teething troubles.
doi:10.1038/441405a
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Correspondence
Climate: open review may ease acceptance of report p406
Climate: US has always made IPCC drafts available p406
HIV denialists ignore large gap in the study they cite p406
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Books and Arts
Building on failure p407
Working out why something doesn't work is a good starting point for improving the design.
doi:10.1038/441407a
A mammoth murder mystery p408
doi:10.1038/441408a
Electrifying book wins Aventis Prize p408
doi:10.1038/441408b
Everyone hates a know-all p409
doi:10.1038/441409a
Life, the Universe and entropy p409
doi:10.1038/441409b
Science in culture: Form becomes feeling p410
Siobhan Davies looks to science to shape her dance.
Martin Kemp
doi:10.1038/441410a
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News and Views
社会科学：格差のある新世界
Social sciences: A New World of differences p411
For richer, for poorer — the countries of the Americas and those of the Caribbean present stark contrasts in fortune. An explanation of those contrasts invokes branching chains of cause and effect.
Shaun Millerand Jared Diamond
doi:10.1038/441411a
遺伝学：パラミューテーションの可能性
Genetics: Paramutable possibilities p413
A curious genetic phenomenon allows certain genetic instructions to be passed between generations without the gene variants involved being transmitted. Some spotty mice provide clues to how this might happen.
Paul D. Soloway
doi:10.1038/441413a
ナノ材料：折り曲げ可能なディスプレー
Nanomaterials: Display of flexibility p414
Treated the right way, carbon nanotubes can be moulded into large, flexible electron-emitting sheets. The material is one half of what's needed for an electronic display you could fold up and slip in your pocket.
László Forró
doi:10.1038/441414a
免疫学：適応可能な自然の殺し屋
Immunology: Adaptable innate killers p415
Natural killer cells are versatile white blood cells that act in the innate immune system. Quite how adaptable they can be in the absence of other, more specialized, immune cells comes as a surprise.
Peter Parham
doi:10.1038/441415a
隕石学：コンドリュールの作り方
Meteoritics: How to make a chondrule p416
Chondrules, the stony, seed-like grains in meteorites, were formed when some event melted rock in the solar nebula. The latest analyses narrow the possible 'when', 'where' and 'how' of that process.
Steve Desch
doi:10.1038/441416a
生態学：塊のパラドックス
Ecology: Paradox of the clumps p417
A fresh look at an established model in ecology has generated insights into how species coexist with each other. But it has also raised a vexed question: what constitutes the ecological identity of species?
Sean Neeand Nick Colegrave
doi:10.1038/441417a
材料科学：フィルムを評価
Materials science: Film review p418
幹細胞：よいもの、悪いもの、改善可能なもの
Stem cells: Good, bad and reformable p418
The ability of stem cells to continuously supply vast numbers of cells is magnificent, but it can be devastating if it runs amok, as in some tumours. So what makes a normal stem cell turn bad, and can it be redeemed?
Viktor Janzenand David T. Scadden
doi:10.1038/441418b
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Brief Communications
Ecology: Avoidance of disease by social lobsters p421
These gregarious animals shun lobsters that carry a lethal virus, even when they still seem to be healthy.
Donald C. Behringer, Mark J. Butlerand Jeffrey D. Shields
doi:10.1038/441421a
First paragraph | Full Text| PDF (188K) | Supplementary information
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Brief Communications Arising
Correspondence patterns: Mechanisms and models of human dynamics pE5
Correspondence patterns: Mechanisms and models of human dynamics (Reply) pE5
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Insight: Signalling in cancer
Nuclear factor-
Insight: Signalling in cancer -
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Insight: Signalling in cancer
Signalling in cancer p423
Ras, PI(3)K and mTOR signalling controls tumour cell growth p424
Nuclear factor-
B in cancer development and progression p431
Hypoxia signalling in cancer and approaches to enforce tumour regression p437
Jacques Pouysségur, Frédéric Dayanand Nathalie M. Mazure
doi:10.1038/nature04871
New signals from the invasive front p444
Validating cancer drug targets p451
John D. Benson, Ying-Nan P. Chen, Susan A. Cornell-Kennon, Marion Dorsch, Sunkyu Kim, Magdalena Leszczyniecka, William R. Sellersand Christoph Lengauer
doi:10.1038/nature04873
Mechanisms of drug inhibition of signalling molecules p457
Judith S. Sebolt-Leopoldand Jessie M. English
doi:10.1038/nature04874
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Articles
宇宙：長時間持続するγ線バーストと中心核崩壊型超新星は異なった環境に存在する
Long 
-ray bursts and core-collapse supernovae have different environments p463
A. S. Fruchter, A. J. Levan, L. Strolger, P. M. Vreeswijk, S. E. Thorsett, D. Bersier, I. Burud, J. M. Castro Cerón, A. J. Castro-Tirado, C. Conselice, T. Dahlen, H. C. Ferguson, J. P. U. Fynbo, P. M. Garnavich, R. A. Gibbons, J. Gorosabel, T. R. Gull, J. Hjorth, S. T. Holland, C. Kouveliotou, Z. Levay, M. Livio, M. R. Metzger, P. E. Nugent, L. Petro, E. Pian, J. E. Rhoads, A. G. Riess, K. C. Sahu, A. Smette, N. R. Tanvir, R. A. M. J. Wijersand S. E. Woosley
doi:10.1038/nature04787
遺伝：マウスのエピジェネティックな変化のRNAを介した非メンデル遺伝
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse p469
Minoo Rassoulzadegan, Valérie Grandjean, Pierre Gounon, Stéphane Vincent, Isabelle Gillotand François Cuzin
doi:10.1038/nature04674
細胞：白血病を発症させる細胞はPten依存性により造血幹細胞と区別される
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells p475
Ömer H. Yilmaz, Riccardo Valdez, Brian K. Theisen, Wei Guo, David O. Ferguson, Hong Wuand Sean J. Morrison
doi:10.1038/nature04703
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Letters
宇宙：粒子が多く存在する直径数百キロメートル以上の星雲領域におけるコンドリュール形成
Chondrule formation in particle-rich nebular regions at least hundreds of kilometres across p483
Jeffrey N. Cuzziand Conel M. O'D. Alexander
doi:10.1038/nature04834
物理：透過型電子顕微鏡を用いた磁気円二色性の検出
Detection of magnetic circular dichroism using a transmission electron microscope p486
P. Schattschneider, S. Rubino, C. Hébert, J. Rusz, J. Kune
, P. Novák, E. Carlino, M. Fabrizioli, G. Panaccioneand G. Rossi
doi:10.1038/nature04778
工学：Ge/Siナノワイヤーヘテロ構造による高性能電界効果トランジスター
Ge/Si nanowire heterostructures as high-performance field-effect transistors p489
Jie Xiang, Wei Lu, Yongjie Hu, Yue Wu, Hao Yanand Charles M. Lieber
doi:10.1038/nature04796
地球：島弧海底火山の長期噴火活動
Long-term eruptive activity at a submarine arc volcano p494
Robert W. Embley, William W. Chadwick, Jr, Edward T. Baker, David A. Butterfield, Joseph A. Resing, Cornel E.J. de Ronde, Verena Tunnicliffe, John E. Lupton, S. Kim Juniper, Kenneth H. Rubin, Robert J. Stern, Geoffrey T. Lebon, Ko-ichi Nakamura, Susan G. Merle, James R. Hein, Douglas A. Wiensand Yoshihiko Tamura
doi:10.1038/nature04762
進化：酵母の実験個体群でみられる資源競争と社会的対立
Resource competition and social conflict in experimental populations of yeast p498
R. Craig MacLeanand Ivana Gudelj
doi:10.1038/nature04624
進化：グラフおよび社会的ネットワーク上での協力行動の進化に関する単純規則
A simple rule for the evolution of cooperation on graphs and social networks p502
Hisashi Ohtsuki, Christoph Hauert, Erez Liebermanand Martin A. Nowak
doi:10.1038/nature04605
進化：ウミグモでのHox遺伝子発現により明らかになった節足動物の前方付属肢の相同性
Homology of arthropod anterior appendages revealed by Hox gene expression in a sea spider p506
Muriel Jager, Jérôme Murienne, Céline Clabaut, Jean Deutsch, Hervé Le Guyaderand Michaël Manuel
doi:10.1038/nature04591
微生物：ボルバキアの体性幹細胞ニッチ向性
Somatic stem cell niche tropism in Wolbachia p509
Horacio M. Frydman, Jennifer M. Li, Drew N. Robsonand Eric Wieschaus
doi:10.1038/nature04756
細胞：S-ニトロシル化タンパク質ジスルフィドイソメラーゼはタンパク質の折りたたみ異常を神経変性と関連づける
S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration p513
Takashi Uehara, Tomohiro Nakamura, Dongdong Yao, Zhong-Qing Shi, Zezong Gu, Yuliang Ma, Eliezer Masliah, Yasuyuki Nomuraand Stuart A. Lipton
doi:10.1038/nature04782
細胞：PTENは造血幹細胞を維持し、系列選択と白血病予防に作用する
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention p518
Jiwang Zhang, Justin C. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, Jason T. Ross, Jeffrey S. Haug, Dawn Rupp, Kimberly S. Porter-Westpfahl, Leanne M. Wiedemann, Hong Wuand Linheng Li
doi:10.1038/nature04747
腫瘍：核内Aktの機能に拮抗する腫瘍抑制因子ネットワークの同定
Identification of a tumour suppressor network opposing nuclear Akt function p523
Lloyd C. Trotman, Andrea Alimonti, Pier Paolo Scaglioni, Jason A. Koutcher, Carlos Cordon-Cardoand Pier Paolo Pandolfi
doi:10.1038/nature04809
細胞：ダイナミンのGTPに依存するねじれは膜の切断における狭窄と張力に関与する
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission p528
Aurélien Roux, Katherine Uyhazi, Adam Frostand Pietro De Camilli
doi:10.1038/nature04718
細胞：Rec8のリン酸化と組み換えが減数分裂における段階的なコヒーシン消失を促進する
Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis p532
Gloria A. Brar, Brendan M. Kiburz, Yi Zhang, Ji-Eun Kim, Forest Whiteand Angelika Amon
doi:10.1038/nature04794
細胞：細胞のマイクロRNA/短鎖ヘアピンRNA経路の過飽和が原因で起こるマウスの死亡
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways p537
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazarand Mark A. Kay
doi:10.1038/nature04791
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Special Report
Career Views
Naturejobs
ProspectProspect p543
Fledgling UK postdoc association can learn from other efforts.
Paul Smaglik
doi:10.1038/nj7092-543a
Special Report
Animal intelligence p544
Use of animals for testing early in the drug-development process aims to provide vital information to make new drugs safe and effective — and the process is being constantly refined. Hannah Hoag finds out what is involved.
Hannah Hoag
doi:10.1038/nj7092-544a
Career Views
Jai Nagarkatti, president and chief executive, Sigma-Aldrich, St Louis, Missouri p546
Jai Nagarkatti shows loyalty to his company.
Virginia Gewin
doi:10.1038/nj7092-546a
Britain's postdocs unite p546
UK postdocs form association.
John Bothwell
doi:10.1038/nj7092-546b
Clocking out p546
The shifting passage of time in graduate school.
Milan de Vries
doi:10.1038/nj7092-546c
