Figures and Tables

From the following article:

Mechanisms of drug inhibition of signalling molecules

Judith S. Sebolt-Leopold and Jessie M. English

Nature 441, 457-462 (25 May 2006)

doi:10.1038/nature04874

BACK TO ARTICLE
Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Central growth factor signalling pathways that drive pleiotropic cellular responses.

Full size figure and legend (75K)
Figure 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 2

The protein kinase fold: ribbon diagram of MEK1 with bound ATP and PD318088.

Full size figure and legend (62K)
Figure 3 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 3

Alternative binding modes of kinase inhibitors.

Full size figure and legend (44K)
Table 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Table 1

Clinically approved kinase-targeted oncology agents

Full size table and legend
Table 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Table 2

The pipeline: representative kinase-directed oncology drug targets

Full size table and legend
BACK TO ARTICLE