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Figures and Tables

From the following article:

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar and Mark A. Kay

Nature 441, 537-541 (25 May 2006)

doi:10.1038/nature04791

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Figure 1

Hepatocellular toxicity and liver regeneration from shRNA overexpression.

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Figure 2

shRNA overexpression saturates cellular miRNA pathways.

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Figure 3

shRNA overexpression inhibits miR-122 functionality in liver cells.

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Figure 4

AAV/shRNA-mediated persistent HBV inhibition in transgenic mice.

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